B0-field dependence of MRI T1 relaxation in human brain.

NeuroImage
Yicun WangJeff H Duyn

Abstract

Tissue longitudinal relaxation characterized by recovery time T1 or rate R1 is a fundamental MRI contrast mechanism that is increasingly being used to study the brain's myelination patterns in both health and disease. Nevertheless, the quantitative relationship between T1 and myelination, and its dependence on B0 field strength, is still not well known. It has been theorized that in much of brain tissue, T1 field-dependence is driven by that of macromolecular protons (MP) through a mechanism called magnetization transfer (MT). Despite the explanatory power of this theory and substantial support from in-vitro experiments at low fields (<3 ​T), in-vivo evidence across clinically relevant field strengths is lacking. In this study, T1-weighted MRI was acquired in a group of eight healthy volunteers at four clinically relevant field strengths (0.55, 1.5, 3 and 7 ​T) using the same pulse sequence at a single site, and jointly analyzed based on the two-pool model of MT. MP fraction and free-water pool T1 were obtained in several brain structures at 3 and 7 ​T, which allowed distinguishing between contributions from macromolecular content and iron to tissue T1. Based on this, the T1 of MP in white matter, indirectly determined by assum...Continue Reading

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Citations

Nov 15, 2020·Scientific Reports·Jilu P MoleClaudia Metzler-Baddeley
Aug 22, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Daniel J WestShaihan J Malik
Oct 3, 2021·NMR in Biomedicine·Emma BluemkeDaniel Peter Bulte
Jun 17, 2021·Investigative Radiology·Rafael HeissSebastian Bickelhaupt

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