B7-H1 (programmed cell death ligand 1) is required for the development of multifunctional Th1 cells and immunity to primary, but not secondary, Salmonella infection.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Seung-Joo LeeStephen J McSorley

Abstract

Robust Ab and CD4 T cell responses are required for the resolution of Salmonella infection in susceptible mice. In this study, we examined the role of B7-H1 (programmed cell death ligand 1) in resistance to primary Salmonella infection. Infected B7-H1-deficient mice had significantly higher bacterial burdens at day 21 and day 35 postinfection compared with wild-type mice, demonstrating that B7-H1 plays an important role in immunity to Salmonella. B7-H1-deficient and wild-type mice both generated Salmonella-specific IgM and IgG2c Ab responses to infection, and clonal expansion of endogenous and adoptively transferred Salmonella-specific CD4 T cells was similar in both groups. However, although Salmonella-specific IFN-gamma-producing Th1 CD4 T cells were generated in Salmonella-infected B7-H1-deficient mice, these cells did not expand to the level observed in wild-type mice. Furthermore, fewer multifunctional Th1 cells that simultaneously secreted IFN-gamma, TNF-alpha, and IL-2 were detected in Salmonella-infected B7-H1-deficient mice. Together, these data demonstrate that B7-H1 is required for the generation of multifunctional Th1 responses and optimal protective immunity to primary Salmonella infection.

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Citations

Feb 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Nichole K EscalanteJonathan C Choy
Jun 20, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jared H RoweSing Sing Way
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Jul 28, 2011·European Journal of Immunology·Stephen A NewlandAnne Cooke
Apr 18, 2017·The Journal of Clinical Investigation·Todd V Brennan, Yiping Yang
Sep 9, 2019·Trends in Molecular Medicine·Michael S AbersDimitrios P Kontoyiannis
Oct 11, 2020·Cancer Treatment Reviews·Ryosuke HamashimaKoichi Takayama

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