B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Bo JiangDong Hua

Abstract

B7-H3, a member of the B7 family, has been reported to be highly expressed in colorectal cancer and is associated with poor prognosis and overall survival. In this study, we found that overexpression of B7-H3 protected SW80 and HCT8 cells from 5-fluorouracil (5-FU) using CCK-8 assays by inducing resistance to 5-FU chemotherapy. Further investigation has revealed elevated expression of thymidylate synthase (TS) and upregulation of the PI3-kinase (PI3K)/Akt pathway in B7-H3 overexpressing cells. The effects of B7-H3 on activation of the PI3K/Akt pathway and elevation of TS expression could be blocked by LY294002, a specific inhibitor of the PI3K signaling pathway. These results implied that B7-H3 can induce colorectal cancer cell resistance to 5-FU by increasing TS expression and PI3K/Akt/TS signaling and plays an important role during these processes. This study provides more proof concerning the non-immunology effect of B7 molecules, a reminder that both co-stimulatory or inhibitory effects and non-immunology effects should be devoted equal attention.

References

Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mingyi SunChen Dong
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Marc BischofKlaus-Josef Weber
Jul 3, 2007·Cell·Brendan D Manning, Lewis C Cantley
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xingxing Zang, James P Allison
Oct 29, 2008·Oncogene·T F Franke
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Grant ChavinR Jeffrey Karnes
Sep 17, 2009·Current Cancer Drug Targets·S Fulda
Apr 5, 2012·International Journal of Cancer. Journal International Du Cancer·Vibeke Anett IngebrigtsenOystein Fodstad
Dec 18, 2012·International Journal of Molecular Medicine·Xin ZhaoHua Zhao
Mar 12, 2013·The Journal of Investigative Dermatology·Jinhua WangDave S B Hoon
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jun 1, 2014·Cancer Biomarkers : Section a of Disease Markers·Nicola SilvestrisVito Lorusso
Sep 27, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y TangJ Fan
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Feb 17, 2015·World Journal of Gastroenterology : WJG·Ting ZhangDong Hua
Mar 25, 2015·Drugs·Katy K Tsai, Adil I Daud
Jul 3, 2015·EBioMedicine·Paolo A Ascierto, Francesco M Marincola

❮ Previous
Next ❯

Citations

May 18, 2017·Pigment Cell & Melanoma Research·Karine Flem-KarlsenCaroline E Nunes-Xavier
Oct 27, 2017·Oncotarget·Yecheng LiChungen Xing
Apr 11, 2019·Scientific Reports·Karine Flem-KarlsenCaroline E Nunes-Xavier
Mar 28, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jingwen ZhangYing Mao
May 18, 2019·Current Medicinal Chemistry·Karine Flem-KarlsenCaroline E Nunes-Xavier
Jul 24, 2018·Frontiers in Oncology·Peixin DongHidemichi Watari
Jan 19, 2019·Scientific Reports·Ichrak Riahi-ChebbiKhadija Essafi-Benkhadir
Jan 1, 2016·Signal Transduction and Targeted Therapy·Harshita B GuptaTyler J Curiel
Apr 3, 2021·Acta Neuropathologica Communications·Marina DigregorioBernard Rogister
May 25, 2021·Frontiers in Pharmacology·Jii Bum LeeHye Ryun Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.