B7.2 provides co-stimulatory functions in vivo in response to staphylococcal enterotoxin B

European Journal of Immunology
E MurailleO Leo

Abstract

Excessive T cell activation induced by bacterial superantigens plays an important role in the pathology associated with Gram-positive bacteremia. To gain insight into the early phases of T cell activation by bacterial enterotoxins in vivo, we investigated the ability of antibodies to well-defined co-stimulatory molecules to inhibit T cell activation and the subsequent toxic shock syndrome induced in BALB/c mice following the injection of staphylococcal enterotoxin B (SEB). We demonstrate here that a single dose of anti-B7.2 antibodies, but not anti-B7.1 antibodies, significantly inhibits T cell activation, as judged by lower systemic IL-2 release, blastogenesis and IL-2 receptor expression, and reduces the lethal effect of SEB in D-galactosamine-sensitized mice. These results demonstrate that co-stimulation through the B7.2 molecule plays an important role in the activation of T cells in response to SEB in vivo and suggest alternative therapies for septic shock caused by bacterial enterotoxins based on blocking antibodies to co-stimulatory molecules.

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Citations

Oct 30, 1999·Clinical and Experimental Immunology·O Jirapongsananuruk, D Y Leung
Jun 1, 1996·The Journal of Experimental Medicine·B SahaR Abe
Sep 12, 2013·Toxins·Raymond KaempferZiv Rotfogel
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J A GonzaloA J Coyle
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J CelestinR S Geha
Dec 1, 2013·Microbiology Spectrum·Bettina C Fries, Avanish K Varshney

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