Baboon-to-human cardiac xenotransplantation in a neonate
This report details the first case of cardiac xenotransplantation in a neonate. The recipient, a victim of hypoplastic left heart syndrome (HLHS), survived 20 days. Autopsy findings are documented. The cardiac graft showed only traces of cell-mediated rejection. Graft failure appears to have resulted from a progressive, potentially avoidable humoral response, unmodified by immunosuppression. Cardiac allotransplantation and selective baboon-to-human xenotransplantation deserve further exploration as investigational therapy for neonatal HLHS.
Differential patterns of reaction of human natural antibodies to pig hepatocytes and vascular endothelium
The histology at various stages of acute rejection in concordant xenogeneic heart transplantation. A sequential study in rodents
Evidence for a primarily humoral rejection mechanism in concordant xenogeneic heart transplantation. A sequential immunohistological study in a hamster-to-rat model
Report of the Xenotransplantation Advisory Committee of the International Society for Heart and Lung Transplantation: the present status of xenotransplantation and its potential role in the treatment of end-stage cardiac and pulmonary diseases
Fate of infants with hypoplastic left heart syndrome listed for cardiac transplantation: a multicenter study
Management of the hypoplastic left heart syndrome: a challenge to those who care for children with heart diseases
Transplantation as a primary treatment for hypoplastic left heart syndrome: intermediate-term results
Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.