PMID: 2933538Dec 20, 1985

Baboon-to-human cardiac xenotransplantation in a neonate

JAMA : the Journal of the American Medical Association
L L BaileyW B Jolley

Abstract

This report details the first case of cardiac xenotransplantation in a neonate. The recipient, a victim of hypoplastic left heart syndrome (HLHS), survived 20 days. Autopsy findings are documented. The cardiac graft showed only traces of cell-mediated rejection. Graft failure appears to have resulted from a progressive, potentially avoidable humoral response, unmodified by immunosuppression. Cardiac allotransplantation and selective baboon-to-human xenotransplantation deserve further exploration as investigational therapy for neonatal HLHS.

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Related Concepts

Blood Grouping and Crossmatching
Decreased Immunologic Activity [PE]
Autopsy
Pancreatitis, Graft
Lymphocyte Culture Test, Mixed
Papio
Myocardium
Papio anubis
Congenital Heart Defects
Parental Consent

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