Baccharis trimera protects against ethanol induced hepatotoxicity in vitro and in vivo

Journal of Ethnopharmacology
Ana Carolina Silveira RabeloDaniela Caldeira Costa

Abstract

Baccharis trimera has been traditionally used in Brazil to treat liver diseases. To evaluate the protective effect of Baccharis trimera in an ethanol induced hepatotoxicity model. The antioxidant capacity was evaluated in vitro by the ability to scavenged the DPPH radical, by the quantification of ROS, NO and the transcription factor Nrf2. Hepatotoxicity was induced in animals by administration of absolute ethanol for 2 days (acute) or with ethanol diluted for 28 days (chronic). The biochemical parameters of hepatic function (ALT and AST), renal function (urea and creatinine) and lipid profile (total cholesterol, triglycerides and HDL) were evaluated. In addition to antioxidant defense (SOD, catalase, glutathione), oxidative damage markers (TBARS and carbonylated protein), MMP-2 activity and liver histology. Baccharis trimera promoted a decrease in ROS and NO, and at low concentrations promoted increased transcription of Nrf2. In the acute experiment it promoted increase of HDL, in the activity of SOD and GPx, besides diminishing TBARS and microesteatosis. Already in the chronic experiment B. trimera improved the hepatic and renal profile, decreased triglycerides and MMP-2 activity, in addition to diminishing microesteatosis. W...Continue Reading

Citations

Oct 12, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Emran HabibiFatemeh Shaki
Jun 28, 2018·Cellular and Molecular Life Sciences : CMLS·Ning ZhaoTao Zeng
Aug 8, 2019·Journal of Applied Toxicology : JAT·Erika Ramos-Tovar, Pablo Muriel
Mar 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jessica GómezAlejandro Tapia
Dec 19, 2020·Antioxidants·Erika Ramos-Tovar, Pablo Muriel
Aug 28, 2020·Food Research International·Pedro Felipe Pereira ChavesLucimara Mach Côrtes Cordeiro
Sep 22, 2018·Chemico-biological Interactions·Ana Carolina Silveira Rabelo, Daniela Caldeira Costa
Jun 24, 2021·Anais Da Academia Brasileira De Ciências·Tatiane C MendesFrancislaine A Dos Reis Lívero

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