BACE1 levels are increased in plasma of Alzheimer's disease patients compared with matched cognitively healthy controls

Personalized Medicine
Patricia Regina ManzineMárcia Regina Cominetti

Abstract

BACE1 is the secretase that acts in Aβ production in Alzheimer's disease (AD). We investigated mRNA expression in total blood and the levels of plasma protein BACE1 in AD patients compared with cognitively healthy subjects. Probable AD (n = 47) and non-AD control group (n = 32) were evaluated for mRNA expression for BACE1 using reverse transcription-qPCR. A subsample of n = 21 AD and n = 20 non-AD had plasma BACE1 levels analyzed, using ELISA. No differences were found on BACE1 mRNA between groups. However, higher levels of BACE1 were detected in plasma of AD patients. Blood-based diagnostic tools are desired to improve AD diagnosis. BACE1 plasma levels could provide an additional diagnostic tool for AD in association with neuropsychological tests.

References

Oct 1, 1994·Current Opinion in Neurobiology·D J Selkoe
Jun 11, 2002·Biochemical and Biophysical Research Communications·Robert EhehaltPatrick Keller
Jul 12, 2002·Annals of Neurology·R M Damian HolsingerGeneviève Evin
Sep 12, 2002·Archives of Neurology·Hiroaki FukumotoMichael C Irizarry
Nov 20, 2002·Neuroreport·Luisa Benerini GattaDario Finazzi
Jul 15, 2003·The Journal of Biological Chemistry·Ishrut HussainColin Dingwall
Nov 5, 2003·Arquivos de neuro-psiquiatria·Sonia M D BruckiIvan H Okamoto
Aug 6, 2004·Nature·Mark P Mattson
Oct 26, 2005·Biochemical and Biophysical Research Communications·Kiyoko S MurayamaWataru Araki
Apr 15, 2006·Clinical Chemistry·Jan H VerheijenRoeland Hanemaaijer
Jun 14, 2006·Neurobiology of Aging·Roberta Borghi Massimo Tabaton
Dec 19, 2006·Neurobiology of Aging·J A JohnstonA P Passmore
May 22, 2007·Biochemical Society Transactions·J H Stockley, C O'Neill
Nov 17, 2007·Molecular Neurodegeneration·Sarah L Cole, Robert Vassar
Jul 9, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Harald Hampel, Yong Shen
Aug 13, 2008·Archives of Neurology·Henrik ZetterbergKaj Blennow
Feb 18, 2009·Journal of Alzheimer's Disease : JAD·Anja SchroederUlrich Schmitt
Feb 19, 2010·Journal of Alzheimer's Disease : JAD·Sandra D MulderRobert Veerhuis
Oct 12, 2010·Journal of Alzheimer's Disease : JAD·David T R CoulsonJanet A Johnston
Oct 26, 2010·Trends in Biotechnology·Christian Humpel
Apr 5, 2011·Journal of Alzheimer's Disease : JAD·Michael EwersHarald Hampel
Jan 25, 2012·TheScientificWorldJournal·Timo GrimmerRobert Perneczky
Feb 22, 2012·Neuromolecular Medicine·Christoffer RosénHenrik Zetterberg
Apr 10, 2013·Current Alzheimer Research·Soraia BaraoBart De Strooper
Nov 19, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Robert PerneczkyUNKNOWN Alzheimer's Disease euroimaging Initiative
Dec 25, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Heather M SnyderHoward M Fillit
Jun 5, 2014·Current Alzheimer Research·Patty C Kandalepas, Robert Vassar
Aug 7, 2014·Journal of Alzheimer's Disease : JAD·Justin Tao Wen ChiamMartina Sattlecker
Oct 25, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN Alzheimer's Association National Plan Milestone WorkgroupMaria C Carrillo
Mar 21, 2015·Journal of Alzheimer's Disease : JAD·Mary J SavageUNKNOWN Foundation for National Institutes of Health (FNIH) Biomarkers Consortium CSF Proteomics Project Team for Alzheimer's Diseas

❮ Previous
Next ❯

Citations

Jul 11, 2019·Molecular Neurobiology·Inmaculada Lopez-FontJavier Sáez-Valero
Apr 20, 2020·Journal of Molecular Neuroscience : MN·Seyedeh Nazanin HajjriMehdi Mehdizadeh
Oct 18, 2020·Alzheimer's Research & Therapy·Harald HampelUNKNOWN Alzheimer’s Precision Medicine Initiative (APMI)

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked Immunosorbent Assay
blood drawing
electrophoresis
ELISAs
ELISA

Software Mentioned

GraphPad Prism
Stata
MedCalc

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.