BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint

Trends in Immunology
Srividya SwaminathanMarkus Müschen

Abstract

At the pre-B cell receptor (BCR) checkpoint, developing pre-B cells are selected for successful rearrangement of V(H)-DJ(H) gene segments and expression of a pre-BCR. Reduced stringency at this checkpoint may obstruct the B cell repertoire with nonfunctional B cell clones. Earlier studies have described that activation of B cell lymphoma/leukemia (BCL)6 by a functional pre-BCR mediates positive selection of pre-B cells that have passed the checkpoint. This concept is now further elaborated by the recent finding that the BTB and CNC homology 1 basic leucine zipper transcription factor 2 (BACH2) induces negative selection and opposes BCL6 function prior to the pre-BCR checkpoint. Here, we discuss the antagonism between BCL6 and BACH2 during early B cell development, as well as its implications in both repertoire selection and counter-selection of premalignant clones for leukemia suppression.

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May 12, 2015·Cellular Microbiology·Qian WangRichard J Lamont
Aug 16, 2014·Immunological Reviews·Han-Yu ShihJohn J O'Shea
Apr 8, 2016·Clinical Reviews in Allergy & Immunology·Yin ZhouQianjin Lu
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Jan 28, 2021·International Journal of Molecular Sciences·Karolina Bukowska-StrakovaMaciej Siedlar
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Jun 7, 2020·Experimental Gerontology·Verena Labi, Emmanuel Derudder

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