Bacillomycin D: an iturin with antifungal activity against Aspergillus flavus

Journal of Applied Microbiology
A L MoyneS Tuzun

Abstract

In a search for an antifungal peptide with a high activity against Aspergillus flavus, Bacillus subtilis AU195 was selected from a collection of isolates with antagonistic activity against A. flavus. To identify the antifungal peptides, a protein purification scheme was developed based on the detection of the antifungal activity in purified fractions against A. flavus. Two lipopeptides were purified with anion exchange and gel filtration chromatography. Their masses were determined to be 1045 and 1059 m/z with mass spectrometry, and their peptide moiety was identical to bacillomycin D. AU195 synthesized a mixture of two antifungal bacillomycin D analogues with masses of 1045 and 1059, the 14 mass unit difference representing the difference between a C15 and a C16 lipid chain. Both bacillomycin D analogues were active at the same concentration against A. flavus, but the different lipid chain length apparently affected the activity of the lipopeptide against other fungi.

References

Apr 1, 1978·The Journal of Antibiotics·F BessonL Delcambe
May 1, 1986·The Journal of Antibiotics·F PeypouxG Michel
Jul 1, 1986·The Journal of Antibiotics·N VanittanakomG Jung
Apr 1, 1987·The Journal of Antibiotics·F Besson, G Michel
Jul 1, 1970·The Biochemical Journal·J E Walker, E P Abraham
Mar 1, 1982·The Journal of Antibiotics·A MhammediG Michel
Oct 1, 1995·The Journal of Antibiotics·Y KajimuraM Kaneda
Feb 1, 1995·The Journal of Applied Bacteriology·C LeifertA Harbour
Aug 1, 1994·Mycopathologia·M A KlichJ M Bland
Jun 1, 1994·Applied and Environmental Microbiology·L A Silo-SuhJ Handelsman
Feb 1, 1997·Antimicrobial Agents and Chemotherapy·A J DeLuccaT J Walsh

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Citations

Jun 13, 2006·Microbial Ecology·Jeffrey D PalumboNoreen E Mahoney
Nov 13, 2012·Current Microbiology·Csaba VágvölgyiLászló Manczinger
Jul 19, 2012·World Journal of Microbiology & Biotechnology·Simone Raposo CottaLucy Seldin
Mar 24, 2004·Trends in Biotechnology·Pooja Singh, Swaranjit Singh Cameotra
May 20, 2003·Infectious Disease Clinics of North America·Flavio Queiroz-TellesJohn R Graybill
Oct 20, 2005·Journal of Bioscience and Bioengineering·Vaishali J PatelBharat B Chattoo
Nov 20, 2012·Applied and Environmental Microbiology·Zhihui XuRuifu Zhang
Dec 9, 2010·Chemical & Pharmaceutical Bulletin·Dao-Jing ZhangLi Tian
Oct 1, 2013·Biocontrol Science·Caroline F Ajilogba, Olubukola O Babalola
Dec 15, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Jonathan R CoronelAntonio Ortiz
May 29, 2014·Medicinal Research Reviews·Stephen A Cochrane, John C Vederas
Feb 22, 2008·Trends in Microbiology·Marc Ongena, Philippe Jacques
Apr 22, 2015·Computational and Structural Biotechnology Journal·Gajender AletiGünter Brader
Jun 18, 2005·Journal of Applied Microbiology·J S HanJ W Suh
Apr 24, 2010·FEMS Microbiology Reviews·Jos M RaaijmakersMarc Ongena
Oct 22, 2016·International Journal of Food Microbiology·Flávio Fonseca VerasAdriano Brandelli

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Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

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An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.