PMID: 15371927Sep 17, 2004Paper

Bacillus Calmette-Guérin-induced granulomatous hepatitis in a patient with a superficial bladder carcinoma

European Journal of Gastroenterology & Hepatology
Steven M Van OutryvePeter P Michielsen

Abstract

A 71-year-old male patient with a superficial transitional cell carcinoma of the urinary bladder developed high fever and jaundice, accompanied by progressively increasing serum aminotransferase activities, 2 weeks after the fourth local instillation with an attenuated live strain of Mycobacterium bovis [bacillus Calmette-Guérin (BCG)]. A liver biopsy showed non-caseating granulomatous hepatitis. Cultures for mycobacteria were negative. Mycobacterial DNA was not detected in liver tissue using the polymerase chain reaction. Empirical treatment with rifampicin and isoniazid was started, resulting in partial recovery. After 6 months of therapy, however, serum aminotransferase activities were still twice the upper limit of normal. A second liver biopsy still demonstrated several granulomas. Only after addition of prednisolone, liver tests completely normalized. Also histologically the lesions improved dramatically. This suggests that the BCG hepatitis was at least partially caused by a hypersensitivity reaction. Our patient is the first reported case of BCG hepatitis with histological follow-up under therapy.

References

Aug 1, 1976·Journal of Clinical Pathology·J A WhittakerA J Slater
Mar 5, 1998·The New England Journal of Medicine·R BellamyA V Hill
Dec 1, 2000·The Annals of Pharmacotherapy·H PeyrièreD Hillaire-Buys
Jun 14, 2003·Acta otorrinolaringológica española·C DíazJ J Palacios

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Citations

Apr 17, 2009·Annals of Clinical Microbiology and Antimicrobials·Aliye SoyluAli I Tasci
Apr 14, 2011·World Journal of Hepatology·Michail KaklamanosConstantin Goritsas
Nov 18, 2008·European Journal of Internal Medicine·Ibrahim Koral OnalYusuf Bayraktar
Mar 16, 2007·Seminars in Diagnostic Pathology·David E Kleiner
Dec 12, 2018·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Daniel B GreenBernard F King
Jan 24, 2015·International Journal of Surgical Pathology·Brandon T LarsenThomas V Colby
Feb 4, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sean E KennedyJohn A Charlesworth
Dec 7, 2007·La Revue de médecine interne·D Vital DurandH Rousset

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