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Bacillus Calmette-Guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation

bioRxiv

Jun 3, 2014

Christine DeffertKarl-Heinz Krause

Abstract

Patients with chronic granulomatous disease (CGD) lack generation of reactive oxygen species (ROS) through the phagocyte NADPH oxidase NOX2. CGD is an immune deficiency that leads to frequent infections with certain pathogens; this is well documented for S. aureus and A. fumigatus , but...read more

Mentioned in this Paper

Methylobacter bovis
NCF1 protein, human
Tumor Necrosis Factor-alpha
CYBB
Thylacodes aureus
NCF1 gene
Recombinant Interleukin-17
Mutant Proteins
Promoter
NADPH Oxidase
1
1
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Bacillus Calmette-Guerin infection in NADPH oxidase deficiency: defective mycobacterial sequestration and granuloma formation

bioRxiv

Jun 3, 2014

Christine DeffertKarl-Heinz Krause

PMID: 990005835

DOI: 10.1101/005835

Abstract

Patients with chronic granulomatous disease (CGD) lack generation of reactive oxygen species (ROS) through the phagocyte NADPH oxidase NOX2. CGD is an immune deficiency that leads to frequent infections with certain pathogens; this is well documented for S. aureus and A. fumigatus , but...read more

Mentioned in this Paper

Methylobacter bovis
NCF1 protein, human
Tumor Necrosis Factor-alpha
CYBB
Thylacodes aureus
NCF1 gene
Recombinant Interleukin-17
Mutant Proteins
Promoter
NADPH Oxidase
1
1

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Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Chronic Granulomatous Disease

Chronic Granulomatous Disease is an inherited immunodeficiency disorder that is characterized by recurrent infections and granuloma formation. Discover the latest research on Chronic Granulomatous Disease here.

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