Bacillus subtilis DegU acts as a positive regulator for comK expression

FEBS Letters
Mitsuo Ogura, T Tanaka

Abstract

Bacillus subtilis ComK plays a critical role in competence development. We report that B. subtilis degR, a positive regulator for exoenzyme production, is negatively regulated by overproduced ComK caused by a mecA null mutation. To identify a positive regulator for comK expression in the mecA background, mutations that allowed the degR gene to be expressed were screened in Tn10 transposon insertion mutants. As a result, we identified degU insertion mutations as those having such a property. The degU mutation reduced comK-lacZ expression in a competence medium in both the wild-type and mecA cells in sporulation and competence media. These results indicate that the degU gene product acts as a positive regulator for comK expression even under the condition where the negative regulation of comK by MecA is released.

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Citations

May 27, 2008·Journal of Bacteriology·Ayako YasumuraTeruo Tanaka
Aug 12, 2000·Journal of Bacteriology·M Ogura, T Tanaka
Dec 3, 2005·Journal of Bacteriology·Eiji KawachiTeruo Tanaka
Apr 5, 2013·Theoretical Biology & Medical Modelling·Suzy M Stiegelmeyer, Morgan C Giddings
Jun 26, 2007·Molecular Microbiology·Daniël T VerhammeNicola R Stanley-Wall
Jan 2, 2009·Microbiology·Ewan J MurrayNicola R Stanley-Wall
Jan 16, 2008·FEMS Microbiology Letters·Kensuke Tsukahara, Mitsuo Ogura
Jun 26, 2015·PLoS Genetics·Pamela GambaLeendert W Hamoen
Oct 23, 1997·Journal of Bacteriology·M OguraT Tanaka

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