Sep 14, 2019

Bacillus thuringiensis Cry5B is Active against Strongyloides stercoralis in vitro

The American Journal of Tropical Medicine and Hygiene
Sarit CharuchaibovornSurang Nuchprayoon

Abstract

Strongyloidiasis, caused by Strongyloides stercoralis infection, is an important neglected tropical disease that causes significant public health problems in the tropics and subtropics. The disease can persist in hosts for decades and may be life-threatening because of hyperinfection and dissemination. Ivermectin (mostly) and albendazole are the most common anthelmintics used for treatment. Albendazole is suboptimal for this parasite, and although ivermectin is quite effective in immunocompromised patients, a multiple-course regimen is required. Furthermore, reliance on a single drug class for treating intestinal nematodes is a recipe for future failure. Therefore, it is important to discover new anthelmintics to treat or prevent human strongyloidiasis. One promising candidate is the Bacillus thuringiensis crystal protein Cry5B. Cry5B is highly potent against parasitic nematodes, for example, hookworms and Ascaris suum. Here, we investigated the potential of Cry5B against S. stercoralis. Multiple stages of S. stercoralis, including the first larval stage (L1s), infective stage (iL3s), free-living adult stage, and parasitic female stage, were all susceptible to Cry5B as indicated by impairment of motility and decreased viability...Continue Reading

  • References31
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References

  • References31
  • Citations1

Citations

Mentioned in this Paper

Strongyloides stercoralis antigen
In Vivo
Ascaris suum
Treatment Protocols
Cell Motility
Interleukin-3
Strongyloidiasis
Hookworms
Albendazole
Ivermectin

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