Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure

International Journal for Parasitology. Drugs and Drug Resistance
Yan HuRaffi V Aroian

Abstract

Hookworms are intestinal nematode parasites that infect nearly half a billion people and are globally one of the most important contributors to iron-deficiency anemia. These parasites have significant impacts in developing children, pregnant women and working adults. Of all the soil-transmitted helminths or nematodes (STNs), hookworms are by far the most important, with disease burdens conservatively estimated at four million DALYs (Disability-Adjusted Life Years) and with productivity losses of up to US$139 billion annually. To date, mainly one drug, albendazole is used for hookworm therapy in mass drug administration, which has on average ∼80% cure rate that is lower (<40%) in some places. Given the massive numbers of people needing treatment, the threat of parasite resistance, and the inadequacy of current treatments, new and better cures against hookworms are urgently needed. Cry5B, a pore-forming protein produced by the soil bacterium Bacillus thuringiensis (Bt) has demonstrated good efficacy against Ancylostoma ceylanicum hookworm infections in hamsters. Here we broaden studies of Cry5B to include tests against infections of Ancylostoma caninum hookworms in dogs and against infections of the dominant human hookworm, Necat...Continue Reading

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Citations

Sep 14, 2019·The American Journal of Tropical Medicine and Hygiene·Sarit CharuchaibovornSurang Nuchprayoon
Jul 12, 2020·Journal of Invertebrate Pathology·Neil CrickmoreBryony C Bonning
Sep 1, 2020·Experimental Parasitology·Emmanuel Dunstand-GuzmánIván Flores-Pérez
Nov 12, 2020·Biology·Elisa Gamalero, Bernard R Glick
Dec 16, 2020·Antimicrobial Agents and Chemotherapy·Hanchen LiRaffi V Aroian
Nov 27, 2020·International Journal for Parasitology. Drugs and Drug Resistance·John SandersRaffi V Aroian

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Methods Mentioned

BETA
MDA

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