Background contrast modulates kinetics and lateral spread of responses to superimposed stimuli in outer retina

Visual Neuroscience
E S Reifsnider, D Tranchina

Abstract

Surround enhancement (sensitization) is a poorly understood form of network adaptation in which the kinetics of the responses of retinal neurons to test stimuli become faster, and absolute sensitivity of the responses increases with increasing level of steady, surrounding light. Surround enhancement has been observed in all classes of retinal neurons in lower vertebrates except cones, in some primate retinal ganglion cells, and in human psychophysical studies. In theory, surround enhancement could be mediated by two broad classes of mechanisms, which are not mutually exclusive: one in which the kinetics of the transduction linking cone voltage to postsynaptic current in second-order neurons is modulated, and another in which the transformation of postsynaptic current to membrane voltage is modulated. We report here that both classes of mechanism play a role in surround enhancement measured in turtle horizontal cells (HCs). We stimulated the retina by modulating sinusoidally the illuminance of a bar placed at various positions in the HC receptive field. The bar was surrounded by either equally luminant or dim, steady light. Interpretation of responses in the context of a model for the cone-HC network led to the conclusion that t...Continue Reading

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Citations

Aug 10, 2000·Neural Computation·R M Balboa, N M Grzywacz
Feb 28, 2002·Neural Computation·Norberto M Grzywacz, Rosario M Balboa
Dec 7, 2007·Neuroscience and Biobehavioral Reviews·R Brandies, S Yehuda
Dec 21, 2007·Visual Neuroscience·Susmita ChatterjeeNorberto M Grzywacz

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