Background data of spontaneous tumors in F344/DuCrlCrlj rats

Sangyō eiseigaku zasshi = Journal of occupational health
Kenji TakanobuShoji Fukushima

Abstract

We investigated the 2-year survival rate and incidence of spontaneous tumors in F344/DuCrlCrlj rats used in carcinogenicity studies of chemical substances. Records for animals used in the control groups of carcinogenicity studies which were conducted during the last 10 years were obtained from the database of the Japan Bioassay Research Center (JBRC). Six hundred ninety-nine males and 550 females were used in 14 and 11 inhalation studies, respectively, and 500 animals of each sex were used in 10 male and 10 female oral studies. In each study, SPF (specific pathogen free) animals were housed for 2 years (104 weeks) as control groups in the carcinogenicity studies. All animals underwent necropsy and histopathological examination. Each study was conducted in accordance with the Good Laboratory Practice. The incidence of interstitial cell tumors was highest in both inhalation studies and oral studies (inhalation studies 86.1%, oral studies 68.6%). Tumors which had an incidence of 6% or higher were adenoma of the pituitary, C-cell adenoma of the thyroid, and mononuclear cell leukemia (LGL leukemia) of the spleen in male and female rats; fibroma of the subcutaneous tissue, adrenal pheochromocytoma, and islet cell adenoma of the pancr...Continue Reading

References

Apr 1, 1989·Japanese Journal of Cancer Research : Gann·N ItoS Fukushima
Jan 1, 1984·Toxicologic Pathology·J K HasemanG A Boorman
Mar 16, 2013·Occupational and Environmental Medicine·Shinji KumagaiGaku Ichihara
Aug 6, 2013·Journal of Toxicologic Pathology·Yuichi KuroiwaShuzo Okazaki
Oct 25, 2013·Journal of Toxicologic Pathology·Mariko NagataniKazuyuki Uchida
Jun 10, 2014·Inhalation Toxicology·Shigetoshi AisoShoji Fukushima

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Citations

Mar 19, 2016·Journal of Toxicologic Pathology·Yuichi KinoshitaAiro Tsubura
Sep 7, 2018·The Journal of Toxicological Sciences·Shuji OgawaYuji Oishi
Jul 19, 2017·The Journal of Toxicological Sciences·Takashi YamaguchiHideki Wanibuchi
Feb 12, 2019·Journal of Toxicologic Pathology·Satomi FunahashiShinya Toyokuni

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