Background of the FIB-4 index in Japanese non-alcoholic fatty liver disease

Internal Medicine
Takashi Wada, Mikio Zeniya

Abstract

We investigated the distribution and characteristics of the FIB-4 index of liver fibrosis in 1,441 Japanese men (age 50.7±10.2 years) and 304 women (age 53.9±10.3 years) who underwent comprehensive general health checkups and were identified as having non-alcoholic fatty liver disease. With respect to the FIB-4 index, differences according to sex, metabolic indices, and ultrasonic findings were investigated. Among 9,255 individuals who underwent comprehensive general health checkups, 2,750 (29.8%) were found to have mild fatty liver or fatty liver based on ultrasound findings. After excluding patients who consumed ≥150 g alcohol/week (818 individuals), those testing positive for hepatitis B surface antigens or hepatitis C virus antibody (184 individuals), and those for whom data were insufficient (three individuals), we investigated the FIB-4 indices in the remaining 1,745 subjects. There were no sex differences in the FIB-4 index. A total of 1,370 patients (78.5%) exhibited a low cut-off index (COI) (<1.30), 357 (20.5%), exhibited an indeterminate COI (1.30-2.67), and 18 (1.0%) exhibited a high COI (>2.67). There were no associations between the FIB-4 index and the constituent factors of metabolic syndrome. In contrast, there ...Continue Reading

References

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Citations

Oct 16, 2015·Expert Review of Gastroenterology & Hepatology·Pegah GolabiZobair M Younossi
Dec 7, 2018·Journal of Gastroenterology and Hepatology·Wataru TomenoAtsushi Nakajima
May 4, 2018·Canadian Journal of Gastroenterology & Hepatology·Hiroshi Miyata, Satoru Miyata

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