Background selection and patterns of genetic diversity in Drosophila melanogaster

Genetical Research
B Charlesworth

Abstract

Theoretical models of the effects of selection against deleterious mutations on variation at linked neutral sites (background selection) are used to predict the relations between chromosomal location and genetic variability at the DNA level, in Drosophila melanogaster. The sensitivity of the predictions to variation in the mutation, selection and recombination parameters on which they are based is examined. It is shown that many features of the observed relations between chromosomal location and level of genetic diversity in D. melanogaster can be explained by background selection, especially if the weak selective forces acting on transposable elements are taken into account. In particular, the gradient in diversity in the distal portion of the X chromosome, and the lack of diversity on chromosome 4 and at the bases of the major chromosomes, can be fully accounted for. There are, however, discrepancies between predicted and observed values for some loci in D. melanogaster, which may reflect the effects of forces other than background selection.

References

Mar 21, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D L Lindsley, L Sandler
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R GangulyR Krishnan
Jan 22, 1992·Proceedings. Biological Sciences·X M Li
Jul 1, 1992·Mechanisms of Development·M J BertramM F Wolfner
Jan 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G L Miklos, J N Cotsell
Dec 1, 1989·The Journal of Cell Biology·R E Karess, D M Glover
Dec 1, 1989·Genetics·N L KaplanC H Langley
Dec 1, 1988·Genetical Research·C H LangleyB Charlesworth
May 1, 1987·Genetics·R R HudsonM Aguadé
Feb 1, 1974·Genetical Research·J M Smith, J Haigh
Jun 1, 1995·Genetics·N H Barton

❮ Previous
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Citations

Feb 15, 2001·Trends in Genetics : TIG·A S Kondrashov
Dec 7, 2002·Gene·Bret A Payseur, Michael W Nachman
Oct 30, 2001·Current Opinion in Genetics & Development·P Andolfatto
Mar 13, 2013·Nature Reviews. Genetics·Asher D Cutter, Bret A Payseur
Jan 1, 2009·Genome Biology and Evolution·Jeffrey D Jensen
Jan 26, 2012·Genome Biology and Evolution·José L CamposPenelope R Haddrill
Nov 30, 2012·Genome Biology and Evolution·David W Hall, Marta L Wayne
May 31, 2008·Molecular Biology and Evolution·John E Pool, Rasmus Nielsen
Dec 4, 2012·Molecular Biology and Evolution·Jose L CamposPenelope R Haddrill
Dec 12, 2012·Molecular Biology and Evolution·Melissa A Wilson Sayres, Kateryna D Makova
Jul 26, 2002·Nucleic Acids Research·Brian W KirkFrancis Barany
Oct 27, 1999·Proceedings. Biological Sciences·J Vieira, B Charlesworth
Mar 12, 2002·Proceedings. Biological Sciences·Jonathan R GibsonWilliam R Rice
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B Charlesworth, D Charlesworth
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Peter D Keightley, Adam Eyre-Walker
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Wolfgang Stephan
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Laurence Loewe, William G Hill
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Yuh Chwen G Lee, Charles H Langley
Jul 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·N H Barton
Apr 27, 2012·Genome Research·Daniel GarriganDaven C Presgraves
Nov 10, 2001·Annual Review of Genomics and Human Genetics·M Kreitman
Feb 8, 2007·Genome Biology·Penelope R HaddrillBrian Charlesworth
Oct 13, 2006·PLoS Genetics·Jean-Claude WalserMartin E Feder
Jun 9, 2009·PLoS Genetics·Guy SellaPeter Andolfatto
Oct 17, 2012·PLoS Genetics·Josep M ComeronSamuel Bailin
Jan 6, 2007·PloS One·Bryant F McAllister, Amy L Evans
Dec 22, 2004·Genetics·Andrea J BetancourtH Allen Orr

❮ Previous
Next ❯

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