Baclofen attenuates fMRI alcohol cue reactivity in treatment-seeking alcohol dependent individuals.

Psychopharmacology
Warren B LoggeKirsten C Morley

Abstract

Baclofen has been shown to effect fMRI alcohol cue reactivity in alcohol dependence, but potential varying effects related to baclofen dose levels have not been examined. This study investigated whether baclofen attenuates craving and alcohol cue-elicited activation in alcohol-dependent treatment seekers, and the relationship between this response and clinical outcomes (Morley et al. 2018; Morley et al. 2013). Participants included 30 alcohol-dependent individuals who had received daily baclofen 30 mg (n = 11), 75 mg (n = 8) or placebo (n = 11) for at least 2 weeks. Using functional magnetic resonance imaging (fMRI), we examined alcohol cue-elicited neural activation during a visual alcohol cue reactivity task 120 min following treatment administration, and alcohol cue reactivity and percentage of heavy drinking days (% HDD) associations were assessed. Both baclofen-treated groups reported fewer post-scan % HDD when compared to the placebo-treated group, but no subjective craving group differences were found. Increased alcohol cue-elicited activation was seen in placebo compared to the 75 mg/day baclofen participants in two clusters spanning prefrontal regions implicated in cue reactivity, chiefly frontal regions (i.e., frontal...Continue Reading

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Citations

Apr 25, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ariel KetchersideReagan Wetherill
Aug 7, 2019·Alcoholism, Clinical and Experimental Research·Erica N Grodin, Lara A Ray
Mar 6, 2021·Neuroscience and Biobehavioral Reviews·Nicolaj MistarzAngelina Isabella Mellentin
Mar 19, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Kirsten C MorleyPaul S Haber
Jun 26, 2021·Neuroscience and Biobehavioral Reviews·Jianguang ZengXun Yang
Aug 20, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ahmet O CeceliRita Z Goldstein

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