Baclofen-induced toxicity in renal disease with neurotoxicity and skin rash

Proceedings
Lakshmi Kant PathakIan Martinez

Abstract

Baclofen is approved by the Food and Drug Administration for spasticity and is also used off-label for trigeminal neuralgia, cluster headache, and substance abuse dependency. Baclofen is 90% renally excreted and has a variable threshold for toxicity in patients with chronic kidney disease. We present a case of accidental overdose of baclofen in a 58-year-old woman with intractable trigeminal neuralgia. She presented with baclofen neurotoxicity symptoms including confusion and tremors and had a morbilliform rash in the dorsum of both hands. This simultaneous presentation is rare and has never been reported. Her symptoms resolved after hemodialysis treatment.

References

Jul 1, 1986·Annals of Emergency Medicine·R GerkinR D Meinhart
Dec 24, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Vin-Cent WuCheng-Chung Fang
Dec 2, 2010·Journal of Clinical Pharmacology·Sahoo SaddichhaVivek Benegal
Jan 15, 2014·Journal of Clinical Pharmacology·Raphaël VlavonouMario Tanguay
Sep 14, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Erin WolfMatthew A Sparks

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