PMID: 2509234Nov 1, 1989Paper

Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice

Experimental Neurology
D V LewisD D Mott

Abstract

In rat hippocampal slices, low concentrations of (+/-) baclofen (0.1 to 1.5 microM) elicited spontaneous, rhythmic sharp waves (SRSWs). These low amplitude (0.1 to 0.3 mV) SRSWs were visible with high amplification in the extracellular recordings from the CA1, CA2, and CA3 regions and were roughly synchronous in all areas. SRSW amplitude increased and frequency decreased as baclofen concentration increased up to 1.5 microM, but SRSWs were suppressed at concentrations of 5 microM and higher. The amplitude of the SRSWs was greater in the strata radiatum and the lacunosum moleculare than in the stratum pyramidale. (-)-Baclofen was much more potent in eliciting SRSWs than (+)-baclofen. Low concentrations of baclofen also caused the extracellular excitatory postsynaptic potential in the stratum radiatum of CA3b evoked by stimulation of the Schaffer collaterals to broaden and develop a secondary peak. Slices pretreated with pertussis toxin required much higher concentrations of baclofen to elicit the SRSWs, indicating that the baclofen may be eliciting the SRSWs through a G protein-sensitive mechanism. Baclofen has both inhibitory and disinhibitory effects on neurons. The appearance of these spontaneous population events suggests tha...Continue Reading

Citations

Aug 6, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·J M ErreaJ de Pedro-Cuesta
Jan 1, 1995·Pharmacology & Therapeutics·D I Kerr, J Ong
Jun 2, 2005·Neuroscience Letters·Laura Lee ColginGary Lynch
Dec 5, 2003·Neuropharmacology·Massimo AvoliAmer Omar
Aug 8, 1990·The Journal of Comparative Neurology·Y SamsonJ N Davis
Jun 23, 1998·Canadian Journal of Physiology and Pharmacology·G V Obrocea, M E Morris
Nov 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Rita MotalliMassimo Avoli
Aug 13, 1999·Journal of Neurophysiology·R MotalliM Avoli

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