Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

Brain Research
K YangY Li

Abstract

We investigated the action of baclofen, an agonist for GABA(B) receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Adelta fibers. Baclofen (10 microM) reduced the amplitude of Adelta fiber-evoked glycine receptor-mediated IPSCs to 20.9+/-3.0% (n=13), and GABA(A) receptor-mediated IPSCs to 18.6+/-3.4% (n=12) of the controls, respectively. The results further suggest modulatory role of GABA(B) receptor in spinal dorsal horn.

References

Oct 25, 1991·Brain Research·I KangrgaM Randić
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Sep 21, 2000·The European Journal of Neuroscience·S TowersN G Bowery

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Citations

Mar 9, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Alexander G Rabchevsky, Patrick H Kitzman
Sep 21, 2002·Brain Research Bulletin·Kun YangYun-Qing Li
Feb 14, 2006·Journal of Pharmacological Sciences·Jen-Kun Cheng, Lih-Chu Chiou

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