PMID: 11334090May 4, 2001Paper

Baclofen overdose in two siblings

Pediatric Emergency Care
D ChappleR Connors

Abstract

Baclofen is a muscle relaxant used in both adults and children with neuromuscular disorders to control spasticity. In children, relatively few cases of overdose have been previously reported. We report two cases of baclofen overdose occurring in two siblings. One sibling with cerebral palsy was being treated with baclofen at the time of overdose. Both cases presented with severe respiratory depression requiring mechanical ventilation. Serum baclofen concentrations from both children were significantly elevated. We also review the published literature on baclofen overdose in children and adolescents. These cases emphasize the importance of warning parents about the potential toxicity of baclofen when prescribing the drug to a family member.

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Citations

Feb 26, 2004·The Journal of Emergency Medicine·Ronald N YehRita Ayyangar
May 3, 2006·Pediatric Emergency Care·Kelly W ShirleyTerry A Adirim
Nov 22, 2008·International Journal of Obstetric Anesthesia·W Ali Sakr EsaS Barsoum
Sep 29, 2015·Pediatric Neurology·Catherine SechristNicole Cain
Feb 4, 2006·Emergency Medicine Australasia : EMA·Nicola Y LeungGeoffrey K Isbister
Feb 7, 2006·Pediatric Neurology·Angela F SlaughterShamel A Abd-Allah
Oct 26, 2005·Pediatric Neurology·Farzana P DarbariSanjeev V Kothare
Mar 14, 2013·Journal of Child Neurology·Elena CaronJames W Wheless
Sep 10, 2018·Acta neurologica Belgica·Alper KokerTolga Köroğlu
Jul 9, 2020·Child Neurology Open·Ram A MishaalDouglas G Matsell
Mar 3, 2021·Pediatric Emergency Care·Rachel P PearsonAnjalee W Galion
Nov 7, 2019·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C de MarcellusM Oualha

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