PMID: 3753957Jan 1, 1986Paper

BACOMP--database of bioactive compounds for structure-activity relationship

International Journal of Bio-medical Computing
I K PajevaG V Dimitrov

Abstract

BACOMP database is presented for structure-activity relationship (SAR) investigations; it was realized on a BK-1300 general purpose microcomputer using the MICRO-SETOR network database management system. Some general considerations of database design are given and the models and facilities for a development of a microcomputer-based SAR oriented database are described. The database contains the following information for the bioactive compounds: chemical structures, biological activities, trade names, reference numbers and information sources. For computer representation of chemical structures SAR oriented language is used. The database software includes: system software, data capture and data editing software, information retrieval and data processing applications. The software development is done in FORTRAN IV and MACRO assembly language. The programs are written in a completely interactive mode. The information retrieval software includes 12 functions giving an information for the database as a whole and for a single compound as well. The data processing software includes 8 functions for finding common structural fragments among compounds with similar biological activity and for estimating a structural similarity between diffe...Continue Reading

References

Apr 1, 1977·Journal of Medicinal Chemistry·L HodesS Richman
May 1, 1974·Journal of Medicinal Chemistry·R D CramerC E Berkoff
Feb 1, 1981·Journal of Chemical Information and Computer Sciences·D LefkovitzH Hill
Feb 1, 1981·Journal of Chemical Information and Computer Sciences·J Tinker
May 1, 1981·Journal of Chemical Information and Computer Sciences·J BeckerG Ohnacker

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