Bacteraemia variation during the COVID-19 pandemic; a multi-centre UK secondary care ecological analysis.

BMC Infectious Diseases
Sarah DennyLuke S P Moore

Abstract

We investigated for change in blood stream infections (BSI) with Enterobacterales, coagulase negative staphylococci (CoNS), Streptococcus pneumoniae, and Staphylococcus aureus during the first UK wave of SARS-CoV-2 across five London hospitals. A retrospective multicentre ecological analysis was undertaken evaluating all blood cultures taken from adults from 01 April 2017 to 30 April 2020 across five acute hospitals in London. Linear trend analysis and ARIMA models allowing for seasonality were used to look for significant variation. One hundred nineteen thousand five hundred eighty-four blood cultures were included. At the height of the UK SARS-CoV-2 first wave in April 2020, Enterobacterales bacteraemias were at an historic low across two London trusts (63/3814, 1.65%), whilst all CoNS BSI were at an historic high (173/3814, 4.25%). This differed significantly for both Enterobacterales (p = 0.013), CoNS central line associated BSIs (CLABSI) (p < 0.01) and CoNS non-CLABSI (p < 0.01), when compared with prior periods, even allowing for seasonal variation. S. pneumoniae (p = 0.631) and S. aureus (p = 0.617) BSI did not vary significant throughout the study period. Significantly fewer than expected Enterobacterales BSI occurred d...Continue Reading

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Citations

Oct 2, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nina ZhuAlison Holmes
Oct 25, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rishma AmarsyUNKNOWN “la Collégiale de Bactériologie–Virologie–Hygiène de l'Assistance Publique – Hôpitaux de Paris”

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