Bacteremia complicating gram-negative urinary tract infections: a population-based study.

The Journal of Infection
Majdi N Al-HasanLarry M Baddour

Abstract

Urinary tract infection (UTI) is common and bacteremia complicating this infection is frequently seen. There has been limited data published that characterize bacteremic UTI in a population-based setting over an extended period. We therefore examined the incidence rate, microbiology, outcome, and in vitro antimicrobial resistance trends of bacteremic UTI due to gram-negative bacilli in Olmsted County, Minnesota, from 1/1/1998 to 12/31/2007. We used Kaplan-Meier method to estimate mortality rates, Cox proportional hazard regression to determine risk factors for mortality, and logistic regression to examine temporal changes in antimicrobial resistance rates. We identified 542 episodes of bacteremic gram-negative UTI among Olmsted County residents during the study period. The median age of patients was 71 years and 65.1% were females. The age-adjusted incidence rate per 100,000 person-years was 55.3 (95% confidence interval [CI]: 49.5-61.2) in females and 44.6 (95% CI: 38.1-51.1) in males. Escherichia coli was the most common pathogen (74.9%). The 28-day and 1-year all-cause mortality rates were 4.9% (95% CI: 3.0-6.8) and 15.6% (95% CI: 12.4-18.8), respectively. Older age was associated with higher mortality; community-acquired in...Continue Reading

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Citations

May 9, 2012·BMC Research Notes·Jane-Francis Tatah Kihla AkoachereEsemu Nkie Seraphine
Dec 18, 2013·PLoS Pathogens·Sargurunathan SubashchandraboseHarry L T Mobley
May 11, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chi-Yu ChenChun-Yu Lin
Feb 4, 2014·Infectious Disease Clinics of North America·Betsy Foxman
Mar 26, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yumiko HosakaSatoshi Iwata
Jan 23, 2014·International Journal of Clinical Practice·Y M WiJ-H Song
Jan 3, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J P HorcajadaUNKNOWN Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC)
Feb 14, 2015·The Cochrane Database of Systematic Reviews·Harumi GomiRintaro Mori
Mar 25, 2017·Nature Reviews. Drug Discovery·Seth W DickeyMichael Otto
Nov 19, 2010·Postgraduate Medicine·Mazen S BaderAnnie Brooks
Nov 20, 2016·Internal and Emergency Medicine·Antonio LaluezaJosé María Aguado
Apr 2, 2011·Scandinavian Journal of Infectious Diseases·Young Eun HaJae-Hoon Song
May 26, 2017·Frontiers in Cellular and Infection Microbiology·Erin J BrelandMaria Hadjifrangiskou
Jan 16, 2021·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·F Devrimİ Devrim
Mar 12, 2021·Clinical Microbiology Reviews·Caitlyn L HolmesMichael A Bachman
Apr 24, 2021·Chembiochem : a European Journal of Chemical Biology·Johny M NguyenSteven D Townsend
Jul 18, 2015·Microbiology Spectrum·David A HufnagelMatthew R Chapman
Jul 2, 2021·IDCases·Ana DrobeniucNadine Rouphael

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