Bacteremia in hemodialysis patients with hepatitis C

The American Journal of the Medical Sciences
Puja ChebroluKristina W Kintziger

Abstract

Hepatitis C virus (HCV) infection and bacteremia are common comorbidities in hemodialysis patients. A specific relationship between HCV infection and bacteremia has not been defined; however, there is evidence of immune compromise in both HCV-infected and uremic patients, suggesting that this group may be at higher risk for infection. We investigated risk factors and mortality associated with bacteremia in HCV-infected hemodialysis patients from the United States Renal Data System. During the 4-year study period, HCV was present in 2.1% of 355,084 patients initiating hemodialysis. When compared with the total population, the rate of bacteremia was significantly higher in patients with HCV (38.3% versus 21.8%). The adjusted relative risk (RR) for bacteremia was higher in HCV versus all patients (relative risk, 95% confidence interval [CI]) in the presence of methicillin-resistant Staphylococcus aureus infection (2.64, CI: 2.58-2.70 versus 2.32, CI: 2.27-2.38), HIV (1.93, CI: 1.85-2.02 versus 1.86, CI: 1.77-1.95) urinary tract infection (1.79, CI: 1.77, 1.82 versus 1.64, CI: 1.61-1.67) and cirrhosis (1.49, CI: 1.45-1.54 versus 1.29, CI: 1.25-1.34). The hazard ratio (95% CI) for death was higher in HCV versus all patients at 1.69 ...Continue Reading

References

Jan 17, 2002·The New England Journal of Medicine·D J Wyler
Apr 13, 2007·Journal of the American Society of Nephrology : JASN·Kamyar Kalantar-ZadehSander Greenland
Feb 28, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Geoffrey C Nguyen, Paul J Thuluvath
Aug 15, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Sawako KatoBengt Lindholm
Jul 14, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lionel Piroth
Jul 14, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Antonella d'Arminio MonforteUNKNOWN Icona Foundation Study Group
May 7, 2010·Clinical and Translational Science·Alix AshareGary W Hunninghake
Oct 12, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Paul W Eggers
May 17, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Priti R PatelAlexander J Kallen
Jan 29, 2014·Clinical Pharmacology : Advances and Applications·Astrid WendtMarc Bourlière

❮ Previous
Next ❯

Citations

Mar 28, 2018·The International Journal of Artificial Organs·Rebeca García-AgudoFabrizio Fabrizi
Jul 15, 2017·The International Journal of Artificial Organs·Fabrizio FabriziPiergiorgio Messa
Jun 20, 2017·Emerging Infectious Diseases·Thomas J MarrieDean T Eurich
Aug 3, 2021·Diagnostic Microbiology and Infectious Disease·Chloe TomJames E Peacock

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Journal of the American Society of Nephrology : CJASN
Vikas R DharnidharkaKevin C Abbott
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Steffanie A StrathdeeStudy to Reduce Intravenous Exposures Project
AIDS
Femke A E LambersMOSAIC (MSM Observational Study of Acute Infection with hepatitis C) study group
© 2022 Meta ULC. All rights reserved