Bacteria and Antibiotics in Wound Healing

The Surgical Clinics of North America
Michael D Caldwell

Abstract

This review of the literature concerning bacteria, antibiotics and tissue repair shows there are extensive data supporting microbial interference with wound healing once bacterial burden exceeds 104 CFU per unit of measure, The mechanism of bacterial interference lies largely in prolonging the inflammatory phase of tissue repair. Reducing the microbial bioburden allows tissue repair to continue. Systemic and topical antimicrobials appear critical to reducing the bioburden and facilitating repair. The current controversy over the use of antimicrobials in patients with chronically infected wounds, in particular, revolves around the definition of infection. The reliance on classic clinical signs of inflammation to support antimicrobial use in these patients is tenuous due to the lack of correlation of these signs with the microbial burden known to impair tissue repair.

Citations

Sep 24, 2020·The International Journal of Lower Extremity Wounds·Chunjiang YeJianfen Zhang
Dec 31, 2020·Pharmaceutics·Ane EscobarSergio Enrique Moya
Apr 16, 2021·Acta Biomaterialia·Hanif HaidariZlatko Kopecki
May 18, 2021·Frontiers in Cell and Developmental Biology·Paco López-CuevasPaul Martin
Jun 19, 2021·Journal of Global Antimicrobial Resistance·Marco FalconeLuca Dalla Paola
Jul 16, 2021·Advanced Healthcare Materials·Xiao XiaoJun Chen

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