Bacteria-induced aggregation of bioorthogonal gold nanoparticles for SERS imaging and enhanced photothermal ablation of Gram-positive bacteria

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Huijie WangTingting Jiang

Abstract

The challenge in antimicrobial photothermal therapy (PTT) is to develop strategies for decreasing the damage to cells and increasing the antibacterial efficiency. Herein, we report a novel theranostic strategy based on bacteria-induced gold nanoparticle (GNP) aggregation, in which GNPs in situ aggregated on the bacterial surface via specific targeting of vancomycin and bioorthogonal cycloaddition. Plasmonic coupling between adjacent GNPs exhibited a strong "hot spot" effect, enabling effective surface enhanced Raman scattering (SERS) imaging of bacterial pathogens. More importantly, in situ aggregation of GNPs showed strong NIR adsorption and high photothermal conversion, allowing enhanced photokilling activity against Gram-positive bacteria. In the absence of bacterial strains, GNPs were dispersed and showed a very low photothermal effect, minimizing the side effects towards surrounding healthy tissues. Given the above advantages, the bioorthogonal theranostic strategy developed in this study may find potential applications in treating bacterial infection and even multidrug-resistant bacteria.

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Citations

Aug 18, 2020·Beilstein Journal of Nanotechnology·Mykola BorzenkovGiuseppe Chirico
Feb 11, 2021·Biomaterials Science·Minjie XuQinglian Hu
Sep 6, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuan ChenQiang Peng
Nov 14, 2020·Advanced Healthcare Materials·Guijian GuanMing-Yong Han
Nov 16, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Luyao WangZhijun Zhang

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Methods Mentioned

BETA
surface enhanced Raman scattering
dynamic light scattering
enzyme linked immunosorbent assay
NMR
dynamic
transmission electron microscopy
surface plasmon resonance
imaging technique

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