PMID: 26349116Sep 10, 2015Paper

Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--Special references to bacteria isolated between July 1982 and March 2012

The Japanese journal of antibiotics
Nagao Shinagawa, Mitsuhiro Iwasaki

Abstract

This is an integrated summary of the results obtained from a 3-decade multicenter study on bacteria isolated from surgical infections in Japan between July 1982 and March 2012. During the 3-decade study, 11,196 strains were isolated from 4,787 patients consisting of 2,132 patients with primary infection and 2,655 patients with surgical site infection. Almost half of the primary infection was peritonitis, which accounted for 42.3%-55.5%. In contrast, most of the surgical site infection was wound infection, which accounted for 49.3%-66.1%. The most commonly isolated bacteria throughout three decades were Escherichia coli (1,164 strains), Enterococcus faecalis (842), Staphylococcus aureus (833), Pseudomonas aeruginosa (706), Bacteroides fragilis (705), Klebsiella pneumoniae (498), Enterobacter cloacae (391) and coagulase-negative staphylococci (CNS) (325). Overall, S. aureus and CNS had sensitivity for vancomycin, whose MIC90s were 0.78 to 3.13 μg/mL; E. faecalis had sensitivity for vancomycin and imipenem, whose MIC90s were 0.78-4 μg/mL; E coli, E. cloacae, K. pneumoniae, and B. fragilis had preferable sensitivity for imipenem. No antibacterial agents had a long-term good activity (e.g. MIC90 < 2 μg/mL) for P aeruginosa and Bilop...Continue Reading

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