Bacteria, phages and septicemia

PloS One
Ausra GaidelyteDennis H Bamford

Abstract

The use of phages is an attractive option to battle antibiotic resistant bacteria in certain bacterial infections, but the role of phage ecology in bacterial infections is obscure. Here we surveyed the phage ecology in septicemia, the most severe type of bacterial infection. We observed that the majority of the bacterial isolates from septicemia patients spontaneously secreted phages active against other isolates of the same bacterial strain, but not to the strain causing the disease. Such phages were also detected in the initial blood cultures, indicating that phages are circulating in the blood at the onset of sepsis. The fact that most of the septicemic bacterial isolates carry functional prophages suggests an active role of phages in bacterial infections. Apparently, prophages present in sepsis-causing bacterial clones play a role in clonal selection during bacterial invasion.

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Citations

Nov 3, 2009·Environmental Microbiology·Forest RohwerDebbie Lindell
Oct 24, 2012·Virology·Hanna M OksanenDennis H Bamford
Jun 16, 2015·Frontiers in Microbiology·Tasha M Santiago-RodriguezDavid T Pride
Aug 24, 2012·PloS One·Lauren R FreschaufMichelle Khine
Dec 1, 2011·Microbiology and Molecular Biology Reviews : MMBR·Mart KrupovicDennis H Bamford
Sep 13, 2019·Journal of Clinical Medicine·Cátia PacíficoFriederike Hilbert
Nov 19, 2019·Frontiers in Microbiology·Cátia PacíficoFriederike Hilbert
Feb 16, 2019·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Hayk Minasyan
Oct 21, 2020·Pathogens·Andrzej GórskiRyszard Międzybrodzki

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Methods Mentioned

BETA
blood collection
electrophoresis

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