Bacteria-specific antibody in the urine of patients with acute pyelonephritis and cystitis

The Journal of Infectious Diseases
J J RatnerM Forland

Abstract

Urine specimens from 65 adult patients with symptomatic urinary tract infections that involved 91 episodes of well-defined acute pyelonephritis or cystitis were tested for antibody-coated bacteria (ACB) by a fluorescent antibody assay, unbound bacteria-specific antibody by radioimmunoassay (RIA), and levels of total protein and IgG. Acute pyelonephritis was associated with positive tests for ACB (22 [69%] of 32), elevated levels of unbound antibody (28 [88%] of 32), and a mean RIA binding ratio of 9.4. Cystitis was associated with negative tests for ACB (56 [95%] of 59), low levels of antibody in urine (38 [64%] of 59), and a mean RIA binding ratio of 3.2. The results showed that a negative test for ACB may occur with elevated levels of unbound antibody in the urine because, although elevated, levels were still too low to result in detectable antibody coating of the bacteria. There was often, but not always, a correlation between RIA binding ratios and levels of urinary protein and IgG.

Citations

Jul 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M G Morgan, H McKenzie
Aug 4, 1984·British Medical Journal·G H SchardijnW J Nooyen
Aug 1, 1986·The American Journal of the Medical Sciences·J J RatnerM Forland
Jan 1, 1982·Kidney International·V L Thomas, M Forland
Sep 22, 2015·Nature Reviews. Immunology·Soman N Abraham, Yuxuan Miao
Jan 11, 2008·Clinical and Vaccine Immunology : CVI·Anu KanteleJussi M Kantele
Nov 1, 1984·Journal of Bacteriology·B NowickiT K Korhonen
Jan 14, 2017·Microbiology Spectrum·Byron W Hayes, Soman N Abraham

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