Bacterial acyltransferases as an alternative for lipase-catalyzed acylation for the production of oleochemicals and fuels

Angewandte Chemie
Tim Stöveken, Alexander Steinbüchel

Abstract

Bacterial acyltransferases are a new class of enzymes, and the first member was identified as WS/DGAT in Acinetobacter baylyi ADP1. Their unspecificity have been used in several biotechnological applications for lipid modification, a field that has been dominated by the use of lipases. Examples are the biosynthesis of jojoba-like wax esters and fatty-acid ethyl esters. In addition, these enzymes are also capable of synthesizing acylthioesters. Acyloxoesters and acylthioesters can thus be produced in vivo by whole-cell fermentations rather than in vitro in an enzyme reactor. In this Minireview, we focus on the biotechnological utilization of acyltransferases for the production of modified lipids from renewable resources.

References

Sep 1, 1977·Journal of General Microbiology·K BrynK Bovre
Jan 1, 1976·Biochemical Society Transactions·L M Fixter, J G McCormack
Jul 3, 1975·Nature·T NakajimaI Tabushi
Jan 1, 1996·Progress in Lipid Research·R Lehner, A Kuksis
Sep 10, 1998·International Journal of Systematic Bacteriology·M M YakimovK N Timmis
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·S CasesR V Farese
Feb 24, 2001·Advances in Biochemical Engineering/biotechnology·A Steinbüchel, S Hein
Feb 14, 2002·Journal of Biotechnology·Marc J E C van der MaarelL Dijkhuizen
Feb 22, 2002·European Journal of Biochemistry·Veit BergendahlMohamed A Marahiel
Sep 11, 2002·Trends in Biotechnology·Uwe T BornscheuerSajja Hari Krishna
Oct 9, 2002·Microbiology·Natalie J GartonMichael R Barer
Dec 6, 2002·Applied Microbiology and Biotechnology·H M Alvarez, A Steinbüchel
Dec 17, 2002·Current Opinion in Biotechnology·Uwe T Bornscheuer
May 6, 2003·The Journal of Biological Chemistry·Jingsong CaoYuguang Shi
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kenolisa C OnwuemeLuis E N Quadri
May 5, 2004·The Journal of Biological Chemistry·John BuglinoChristopher D Lima
Dec 3, 2004·Applied and Environmental Microbiology·Rainer KalscheuerAlexander Steinbüchel
Feb 8, 2006·Applied and Environmental Microbiology·Rainer KalscheuerAlexander Steinbüchel
May 2, 2006·Cellular and Molecular Life Sciences : CMLS·K Athenstaedt, G Daum
Aug 1, 2006·Nature Biotechnology·Susanne SchneikerPeter N Golyshin
Jun 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Pawan KumarCarolyn R Bertozzi
Jul 3, 1998·Angewandte Chemie·Rolf D Schmid, Robert Verger

❮ Previous
Next ❯

Citations

Nov 26, 2008·Applied Microbiology and Biotechnology·Sanjib Kumar Karmee
Aug 29, 2009·Applied Microbiology and Biotechnology·Yong Cheol ParkGeorge N Bennett
Jun 12, 2012·Applied and Environmental Microbiology·Brett M BarneyLance C Seefeldt
Oct 23, 2012·Applied and Environmental Microbiology·Brett M BarneyJanet M Ohlert
Oct 4, 2011·Microbial Cell Factories·Suvi SantalaVille Santala
Jan 11, 2014·Biotechnology for Biofuels·Helge Jans Janßen, Alexander Steinbüchel
Mar 13, 2014·Nature Chemical Biology·Brett M Barney
Sep 9, 2010·Annual Review of Genetics·Tiangang Liu, Chaitan Khosla
Aug 28, 2009·Current Opinion in Microbiology·Véronique de BerardinisMarcel Salanoubat
May 19, 2009·Current Opinion in Microbiology·Mathew A Rude, Andreas Schirmer
Jul 25, 2015·Applied Microbiology and Biotechnology·Brett M BarneyAmelia M Lijewski
Oct 29, 2011·IUBMB Life·Kathryn T Elliott, Ellen L Neidle
Dec 12, 2012·Bioengineered·Hui LinYuhua Zhao
Apr 8, 2011·Angewandte Chemie·Ursula BiermannHans J Schäfer
May 24, 2013·Microbiology and Molecular Biology Reviews : MMBR·Annika Röttig, Alexander Steinbüchel
Mar 5, 2018·Applied Microbiology and Biotechnology·Magdalena MiklaszewskaFrédéric Domergue
Dec 11, 2020·FEMS Microbiology Letters·Amelia M LijewskiBrett M Barney
May 7, 2010·Journal of Chemical Information and Modeling·Ying WangJing-Fang Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.