PMID: 16505552Mar 1, 2006Paper

Bacterial adherence and humoral immune response in women with symptomatic and asymptomatic urinary tract infection

Indian Journal of Medical Microbiology
S EthelB M Hegde

Abstract

To determine the role of humoral immune response and bacterial adherence in the pathogenesis of symptomatic and asymptomatic urinary tract infection in women. The study population consisted of 30 women with symptomatic UTI, 30 women with asymptomatic UTI and 30 healthy women as controls. Bacterial adherence to vaginal epithelial cells was studied and the concentration of serum and urine antibodies to mixed coliform antigen and clinical isolate was determined by ELISA. Surface hydrophobicity of the urine isolates was determined. Student's unpaired t test and Pearson's correlation coefficient test were used in the statistical analysis. Compared to asymptomatic UTI, significantly more number of bacteria adhered to the epithelial cells of women with symptomatic UTI (P< 0.001). All cases of UTI had significantly high concentration of urinary IgG antibody to mixed coliform antigens. Asymptomatic UTI cases had higher concentrations of urinary IgG, IgM and IgA antibodies to clinical isolate. Concentration of sIgA level was more in symptomatic UTI. Significant correlation was observed between urinary IgG and adherence of clinical isolate in case of asymptomatic UTI. The present study showed that greater receptivity of epithelial cells t...Continue Reading

Citations

Apr 18, 2014·Indian Journal of Pathology & Microbiology·Seema MittalUma Chaudhary
Apr 9, 2010·Expert Opinion on Investigational Drugs·Marcus Alexander Wörns, Peter Robert Galle
Jul 15, 2020·Nature Reviews. Urology·Livia Lacerda Mariano, Molly A Ingersoll

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