Bacterial adherence to biomaterials and tissue. The significance of its role in clinical sepsis
The direct examination of tissue and biomaterials from prosthesis-related infections of twenty-five patients showed that the causative bacteria grew in glycocalyx-enclosed biofilms that were adherent to surfaces of biomaterials and tissues in 76 per cent. This high rate of recovery of adherent biofilm-mediated growth suggests that the process occurs commonly in the presence of a foreign body or biomaterial-related infection. Because of the adherent mode of growth of the infecting organisms, accurate microbiological sampling was difficult. The analysis of joint fluids or of swabs of excised tissue and of prosthetic surfaces often yielded only one species from what was a polymicrobial population based on electron microscopic studies. We adapted direct quantitative sampling methods from environmental microbiology in order to recover a large number of species from these infections, but comparison of the organisms isolated by these techniques with the morphological types that were seen by electron microscopy indicated that in some instances all bacterial components of the biofilms were still not being recovered.
Strategy to control methicillin-resistant Staphylococcus aureus post-operative infection in orthopaedic surgery
Percutaneous interface biopsy in dry-aspiration cases of chronic periprosthetic joint infections: a technique for preoperative isolation of the infecting organism
Application of temporarily functional antibiotic-containing bone cement prosthesis in revision hip arthroplasty
Successful single-dose prophylaxis of Staphylococcus aureus foreign body infections in guinea pigs by fleroxacin.
Treatment of experimental foreign body infection caused by methicillin-resistant Staphylococcus aureus.
Effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreign body infection.
Analysis of S. Epidermidis icaA and icaD genes by polymerase chain reaction and slime production: a case control study
Gentamicin release from commercially-available gentamicin-loaded PMMA bone cements in a prosthesis-related interfacial gap model and their antibacterial efficacy
Impregnation of bone chips with antibiotics and storage of antibiotics at different temperatures: an in vitro study
Impregnation of bone chips with alendronate and cefazolin, combined with demineralized bone matrix: a bone chamber study in goats
In vitro interactions between bacteria, osteoblast-like cells and macrophages in the pathogenesis of biomaterial-associated infections
Direct demonstration of viable Staphylococcus aureus biofilms in an infected total joint arthroplasty. A case report.
Permanent antibiotic impregnated intramedullary nail in diabetic limb salvage: a case report and literature review
Rationale for one stage exchange of infected hip replacement using uncemented implants and antibiotic impregnated bone graft
PRP as a new approach to prevent infection: preparation and in vitro antimicrobial properties of PRP
Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus epidermidis biofilms isolated from infected total hip arthroplasty cases
Microstructure, mechanical properties, bio-corrosion properties and antibacterial properties of Ti-Ag sintered alloys
Adherence to and accumulation of S. epidermidis on different biomaterials due to extracellular slime production. In vitro comparison of a slime-producing strain (Rp 62 A) and its isogenic slime negative mutant (M7)
Outcome and treatment of postoperative spine surgical site infections: predictors of treatment success and failure
Septic arthritis after arthroscopic cruciate ligament reconstruction: in vitro comparison of the behavior of two types of interference screws towards the Staphylococcus aureus adherence
In vitro investigation of orthopedic titanium-coated and brushite-coated surfaces using human osteoblasts in the presence of gentamycin
In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating
Biofilm & Infectious Disease
Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.