Abstract
Thrombosis and infection are two major complications associated with cardiovascular devices such as ventricular assist devices, total artificial hearts, vascular grafts, and catheters. When blood contacts an artificial biomaterial, protein deposition occurs, as do activation of the blood coagulation cascade, platelet adhesion, activation, and aggregation, all of which lead to thrombus formation. An increased incidence of bacterial infection also has been seen clinically with indwelling biomaterial devices. Some evidence suggests a possible association between thrombosis and infection, in that adherent bacteria may provide a nidus for thrombus formation, or adherent thrombi composed of platelets and fibrin may form sheltered sites for bacterial adhesion. In the current study, the authors examined Staphylococcus aureus adhesion to sulfonated, aminated, and phosphonated polyurethane surfaces that had been pre-adsorbed with solutions of increasing complexity, in an effort to approach and simulate clot formation on the surface. These solutions included various combinations of fibrinogen, albumin, plasma, thrombin, and isolated platelets. Bacterial adhesion was observed in a radial flow chamber mounted on the motorized stage of a vid...Continue Reading
Citations
Sep 4, 1999·The Annals of Thoracic Surgery·W L HolmanJ K Kirklin
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Petr DobsákJiri; Wotke
Aug 21, 2001·Intensive Care Medicine·W L Holman
Mar 11, 2005·Journal of Vascular and Interventional Radiology : JVIR·Suzanne WeckCharles P Semba
Jan 19, 2010·Acta Biomaterialia·J P TheronD Bezuidenhout
Apr 3, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Huichun XuFrank R Sharp
Jan 30, 2008·Journal of Biomedical Materials Research. Part a·A Al-AhmadE Hellwig
Mar 19, 2013·Journal of Biomedical Materials Research. Part a·Amaliris RuizKristyn S Masters
Jan 19, 2000·The Journal of Laboratory and Clinical Medicine·B ShenkmanD Varon
Jul 10, 2003·Critical Care Clinics·Brian R Jacobs
Sep 15, 2001·Journal of Biomaterials Science. Polymer Edition·J H ParkY H Bae
Dec 22, 1998·Journal of Biomaterials Science. Polymer Edition·C D McFarlandJ G Steele
Dec 11, 1999·Journal of Biomaterials Science. Polymer Edition·A KidaneK Park
Apr 13, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Hozan MuftyInge Fourneau
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Jayanti MendhiYin Xiao
Nov 23, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Linhua LiYunbing Wang