Jan 1, 1975

Bacterial and fungal growth in total parenteral nutrition solutions,

Antonie van Leeuwenhoek
M L FaillaE D Weinberg

Abstract

The most serious complication of prolonged intravenous infusion of hypertonic dextrose and amino acids is infection. Frequently, the etiology is fungal rather than bacterial. Previous authors have suggested that bacterial survival and growth in the solutions is suppressed by (a) high dextrose concentration, (b) high osmolality, or (c) low pH. This paper presents evidence that proposals (a) and (b) are untenable and (c) is only partly responsible. We call attention to the presence of a factor that is antibacterial but not antifungal; namely, a high concentration of glycine.

  • References6
  • Citations8

References

Mentioned in this Paper

Drug Impurity
Glycine, Monopotasssium Salt
Candida albicans
Alkalescens-Dispar Group
Amino Acids, I.V. solution additive
Parenteral Route of Drug Administration
Glycine
Etiology
Glycine (Plant)
Pseudomonas aeruginosa

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