Bacterial cell wall components regulate adipokine secretion from visceral adipocytes

Journal of Clinical Biochemistry and Nutrition
Risa TairaToshio Taira

Abstract

Recent studies suggest a relationship between intestinal microbiota and metabolic syndromes; however, the underlying mechanism remains unclear. To clarify this issue, we assessed the effects of bacterial cell wall components on adiponectin, leptin and resistin secretion from rat visceral adipocytes in vitro. We also measured the relative population of Firmicutes and Bacteroidetes in fecal microbiota and the amount of fecal mucin as an intestinal barrier function, when mice were fed a high-fat diet. In the present study, we demonstrated that bacterial cell wall components affect the secretion of adipokines, depending on the presence of antigens from gram-positive or gram-negative bacteria. Lipopolysaccharide markedly inhibited adiponectin, leptin, and resistin secretion, whereas peptidoglycan increased adiponectin secretion and decreased resistin secretion in vitro. In vivo experiments showed that the high-fat diet increased the population of Firmicutes and decreased that of Bacteroidetes. In contrast, the high-fat diet downregulated the stool output and fecal mucin content. These results demonstrate that bacterial cell wall components affect the onset of metabolic syndromes by mediating the secretion of adipokines from visceral...Continue Reading

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Citations

Dec 30, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L-G HersougS Loft
Oct 23, 2015·BioMed Research International·María Teresa Arias-LosteJavier Crespo
Jul 8, 2015·Clinical Biochemistry·Irina A KirpichCraig J McClain
Jun 11, 2016·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A FialhoB Shen
Nov 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·AbuZar AnsariHojun Kim
Mar 16, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T PallisterA M Valdes
Sep 1, 2017·Journal of Obesity & Metabolic Syndrome·Joseph F Cavallari, Jonathan D Schertzer
Jun 7, 2018·Cell Metabolism·Francesca CignarellaLaura Piccio

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Methods Mentioned

BETA
ELISA
PCR

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