Bacterial cell wall products increases stabilization of HIF-1 alpha in an oligodendrocyte cell line preconditioned by cobalt chloride or desferrioxamine

Journal of Neuroimmunology
Song-yi YaoSubramaniam Sriram

Abstract

We examined the effect of lipopolysaccharide (LPS) or lipotechoic acid (LTA) on the regulation of hypoxia inducible factor (HIF-1) alpha on the MO3.13 cells, a human oligodendroglial cell line. Our study shows that MO3.13 cells express the toll like receptors (TLR's) but do not increase cellular levels of HIF-1 alpha following exposure to bacterial cell wall products. When MO3.13 cells were preconditioned by desferrioxamine (DFO) or cobalt chloride (CoCl(2)) and then treated with either LPS or LTA, HIF-1 alpha levels were higher than that induced by DFO or CoCl(2) alone. The increase in HIF-1 alpha was due to increased protein stability that was mediated by activation of the ERK-MAP kinase pathway.

References

Feb 1, 1997·Neurology·S Sriram, M Rodriguez
Jan 23, 1999·Journal of Neuroimmunology·M M HiremathG K Matsushima
Jul 6, 2000·The EMBO Journal·A O AliprantisA Zychlinsky
Mar 21, 2002·Nature Reviews. Cancer·Adrian L Harris
Sep 19, 2003·Antioxidants & Redox Signaling·Nobuhito GodaRandall S Johnson
Jan 31, 2004·Seminars in Immunology·Stephan R Krutzik, Robert L Modlin
Aug 12, 2004·Physiology·Gregg L Semenza
Sep 29, 2004·Journal of Clinical Pathology·A E Greijer, E van der Wall
Sep 30, 2004·Nature Immunology·Donald N CookDavid A Schwartz
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Frank R SharpMyriam Bernaudin
Feb 23, 2005·Current Drug Targets. CNS and Neurological Disorders·Robert S Freeman, Maria Cecilia Barone
Mar 19, 2005·Brain : a Journal of Neurology·Christine StadelmannHans Lassmann
Apr 23, 2005·Brain : a Journal of Neurology·Seth Love
May 4, 2005·Current Neurology and Neuroscience Reports·Xinqing Deng, Subramaniam Sriram
May 4, 2005·Biochemical and Biophysical Research Communications·Ester M Hammond, Amato J Giaccia
May 6, 2005·Brain : a Journal of Neurology·Paul A FeltsKenneth J Smith
Jun 17, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Thomas Hellwig-BürgelWolfgang Jelkmann
Jul 12, 2005·The Journal of Clinical Investigation·Kol A Zarember, Harry L Malech
Oct 18, 2005·The Journal of Biological Chemistry·Ambreena SiddiqRajiv R Ratan
Jan 31, 2006·Journal of the Society for Gynecologic Investigation·Jhodie R DuncanSandra M Rees
Mar 22, 2006·Expert Opinion on Therapeutic Targets·Gregg L Semenza
May 23, 2006·Nature Reviews. Neuroscience·Jeffrey M Gidday
Jun 24, 2006·Seminars in Fetal & Neonatal Medicine·Xiaoyang WangCarina Mallard
Aug 31, 2007·Brain : a Journal of Neurology·Hannelore EhrenreichClaudia Bartels
Oct 25, 2007·Brain : a Journal of Neurology·Christina MarikKenneth J Smith

❮ Previous
Next ❯

Citations

Feb 7, 2009·Journal of Neurochemistry·Michela GuglielmottoMassimo Tabaton
Apr 14, 2016·Cellular Immunology·Wei DengLingyun Sun
Aug 24, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Stefania GessiPier Andrea Borea
Jun 28, 2016·European Journal of Pharmacology·Jungo KatoCamilla I Svensson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis