Bacterial chemotactic oligopeptides and the intestinal mucosal barrier

Gastroenterology
D M FerryV S Chadwick

Abstract

Intestinal absorption and enterohepatic circulation of N-formyl-methionyl-leucyl-125I-tyrosine, a bioactive synthetic analog of the bacterial chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine has been investigated in the rat. In ileum and proximal and distal colon, dithiothreitol, which increases mucosal permeability, increased peptide absorption and biliary recovery fourfold, 70-fold, and 20-fold over control values, respectively. When dithiothreitol was combined with d-l-benzyl succinate, a potent inhibitor of intestinal carboxypeptidase, absorption and biliary recovery from ileal loops increased markedly to 40-fold over control, whereas there was no further increase in absorption from colon loops. There was a strong correlation between biliary N-formyl-methionyl-leucyl-125I-tyrosine recovery and intestinal absorption of 51Cr-ethylenediaminetetraacetate, a marker of passive mucosal permeability (r = 0.97). We conclude that in the ileum both enzymic degradation and restricted mucosal permeability contribute to the intestinal barrier to luminal bacterial formyl oligopeptides. In the colon, however, enzymic mechanisms are less active and restricted mucosal permeability is the major factor. Abnormalities of the intestin...Continue Reading

Citations

Jul 1, 1990·Journal of Gastroenterology and Hepatology·V S ChadwickM F Broom
Mar 22, 2002·Journal of Clinical Gastroenterology·Mark T DeMeoMary C Tobin
Aug 1, 1991·Gut·C MooneyV Chadwick
Mar 4, 2000·Drug Development and Industrial Pharmacy·A Bernkop-SchnürchC Valenta
Sep 2, 2017·Probiotics and Antimicrobial Proteins·Giorgio La FataM Hasan Mohajeri
Jun 1, 1996·Medicine and Science in Sports and Exercise·A J RyanC V Gisolfi
Feb 1, 1992·Digestive Diseases and Sciences·R P AndersonV S Chadwick
May 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·J ShouJ M Daly
Nov 3, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CamilleriHoussam Halawi
Dec 4, 2003·European Journal of Clinical Nutrition·F J TroostR-J M Brummer
Apr 13, 1999·The American Journal of Physiology·D R MackM A Hollingsworth
Aug 1, 1994·Pharmacology & Therapeutics·S P Travis, D P Jewell
Apr 1, 1994·Comparative Biochemistry and Physiology. Biochemistry and Molecular Biology·T Tanaka, E Ichishima
Mar 12, 1992·Biochimica Et Biophysica Acta·R M SherriffV S Chadwick
Apr 17, 2004·The Journal of Investigative Dermatology·Takahiro TsurukiMasaaki Yoshikawa
Jun 1, 1994·Baillière's Clinical Gastroenterology·S P Travis, D P Jewell
Jul 10, 2004·Gastroentérologie Clinique Et Biologique·Tamara Matysiak-BudnikFrancis Mégraud

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