Bacterial clearance and cytokine profiles in a murine model of postsurgical nosocomial pneumonia

Clinical and Diagnostic Laboratory Immunology
Patricia A ManderscheidP R Knight

Abstract

The development of a nosocomial pneumonia is facilitated by alterations in host innate pulmonary antibacterial defenses following surgical trauma, which can result in decreased pulmonary bacterial clearance and increased morbidity and mortality. In a murine model of postoperative nosocomial infection, surgical stress (laparotomy) decreased Escherichia coli clearance from the lungs of animals that underwent surgery. Consistent with previous studies, (i) pulmonary levels of tumor necrosis factor alpha at 6 h and of interleukin-1beta (IL-1beta), IL-6, and gamma interferon (IFN-gamma) at 24 h post-bacterial infection (PBI) were decreased in animals that underwent laparotomy 24 h prior to E. coli infection (LAP/E. coli) compared to animals that received E. coli only; (ii) KC and macrophage inhibitory protein 2 were elevated at 6 h PBI in LAP/E. coli animals compared to E. coli-only animals; however, at 24 h PBI, levels were higher in the E. coli-only group; (iii) at 24 h PBI, monocyte chemoattractant protein 1 was lower in the LAP/E. coli group compared to the E. coli-only group; (iv) IL-10 levels were unaffected at all time points evaluated; and (v) the total number of neutrophils present in the lungs of LAP/E. coli animals at 6 h ...Continue Reading

References

Jul 1, 1992·Journal of Clinical Immunology·M HowardJ de Vries
Apr 1, 1992·Acta Anaesthesiologica Scandinavica·M Salo
Jan 1, 1992·Intensive Care Medicine·J E Pennington
Feb 1, 1990·The Biochemical Journal·P C HeinrichT Andus
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Feb 1, 1990·Immunological Investigations·M K EskandariD G Remick
Feb 1, 1990·The American Review of Respiratory Disease·Y Sibille, H Y Reynolds
Jan 1, 1989·Advances in Immunology·C A Dinarello
Mar 1, 1988·Archives of Surgery·C L Miller-GrazianoK Kodys
Mar 1, 1988·Archives of Surgery·E FaistG Heberer
Dec 1, 1980·Annals of Surgery·A M MunsterP Keeling
Dec 1, 1994·American Journal of Respiratory Cell and Molecular Biology·C W FrevertL Kobzik
Jan 1, 1994·Annual Review of Immunology·S Romagnani
Feb 1, 1993·American Journal of Respiratory Cell and Molecular Biology·J H WilliamsT R Ulich
Jan 1, 1993·The Journal of Surgical Research·J G WilliamsR V Maier
Jul 1, 1996·Biological Signals·T J StandifordS L Kunkel
Oct 1, 1996·FEMS Immunology and Medical Microbiology·L L LaichalkT J Standiford
Oct 1, 1996·Intensive Care Medicine·D J Dries
Jun 1, 1997·Infection and Immunity·T HenslerB Holzmann
Aug 1, 1997·Current Opinion in Immunology·N W Schluger, W N Rom
Jan 1, 1997·British Medical Bulletin·C Haslett
Aug 25, 1999·Anaesthesia·S A HelmyM El-Nawaway

❮ Previous
Next ❯

Citations

May 23, 2007·The Journal of Experimental Medicine·MyTrang NguyenBeverly H Koller
Jan 26, 2011·Critical Care Medicine·Krishnan RaghavendranPaul R Knight
Feb 23, 2010·The Journal of Trauma·Mark A JonkerKenneth A Kudsk
Jan 27, 2010·Infection and Immunity·Jared T MuenzerRichard S Hotchkiss
Jun 24, 2008·Brain, Behavior, and Immunity·Cornelia KiankChristine Schuett
Jul 5, 2011·Microbes and Infection·Fanny RenoisChristophe de Champs
Nov 23, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Brahm H SegalPaul R Knight
Mar 21, 2013·The Journal of Trauma and Acute Care Surgery·Azra BihoracLyle L Moldawer
Mar 22, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Krishnan RaghavendranPaul R Knight
Sep 8, 2017·Journal of Dental Anesthesia and Pain Medicine·Young Gon SonHo Geol Ryu
Apr 8, 2010·Expert Review of Molecular Diagnostics·Philippe Abou JaoudeAli A El-Solh
Aug 24, 2012·The Journal of Trauma and Acute Care Surgery·Nadine DingUlrich A Maus
Feb 20, 2018·The Open Respiratory Medicine Journal·E B HuntD M Murphy
Jan 23, 2021·Stem Cell Reports·Joshua T CohenCraig T Lefort

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.