Bacterial CMP-sialic acid synthetases: production, properties, and applications

Applied Microbiology and Biotechnology
Rahman M Mizanur, Nicola L Pohl

Abstract

Sialic acids are abundant nine-carbon sugars expressed terminally on glycoconjugates of eukaryotic cells and are crucial for a variety of cell biological functions such as cell-cell adhesion, intracellular signaling, and in regulation of glycoproteins stability. In bacteria, N-acetylneuraminic acid (Neu5Ac) polymers are important virulence factors. Cytidine 5'-monophosphate (CMP)-N-acetylneuraminic acid synthetase (CSS; EC 2.7.7.43), the key enzyme that synthesizes CMP-N-acetylneuraminic acid, the donor molecule for numerous sialyltransferase reactions, is present in both prokaryotes and eukaryotic systems. Herein, we emphasize the source, function, and biotechnological applications of CSS enzymes from bacterial sources. To date, only a few CSS from pathogenic bacterial species such as Neisseria meningitidis, Escherichia coli, group B streptococci, Haemophilus ducreyi, and Pasteurella hemolytica and an enzyme from nonpathogenic bacterium, Clostridium thermocellum, have been described. Overall, the enzymes from both Gram-positive and Gram-negative bacteria share common catalytic properties such as their dependency on divalent cation, temperature and pH profiles, and catalytic mechanisms. The enzymes, however, can be categorized ...Continue Reading

References

Nov 1, 1991·Glycobiology·E L Kean
May 1, 1990·Microbial Pathogenesis·A A CampagnariM A Apicella
Dec 1, 1994·Journal of Bacteriology·R F Haft, M R Wessels
Jan 1, 1996·Journal of Bacteriology·W MelaughB W Gibson
Jan 20, 1999·Cellular and Molecular Life Sciences : CMLS·C Traving, R Schauer
Mar 26, 1999·Protein Science : a Publication of the Protein Society·M V TulliusB W Gibson
Jun 9, 2000·Molecular Microbiology·E VimrS Steenbergen
Jun 26, 2001·Glycoconjugate Journal·R Schauer
Oct 2, 2001·Bioscience, Biotechnology, and Biochemistry·K IshigeT Noguchi
Jan 11, 2002·Reviews in the Neurosciences·J Z Kiss, D Muller
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Martina SchwarzkopfRüdiger Horstkorte
Jun 29, 2002·Trends in Microbiology·Eric Vimr, Carol Lichtensteiger
Jul 24, 2002·Protein Expression and Purification·Marie-France KarwaskiMichel Gilbert
Dec 5, 2002·Current Opinion in Structural Biology·Paul R Crocker
Jun 4, 1962·Biochemical and Biophysical Research Communications·L WARREN, R S BLACKLOW
Feb 1, 1964·Biochemistry·E J MCGUIRE, S B BINKLEY
Mar 6, 2004·Trends in Microbiology·Ignacio G BravoAngel Reglero
Jun 18, 2004·Glycobiology·Anja K Münster-KühnelRita Gerardy-Schahn
Oct 26, 2005·Bioscience, Biotechnology, and Biochemistry·Tomoki HamamotoToshitada Noguchi

❮ Previous
Next ❯

Citations

Apr 25, 2012·Applied Microbiology and Biotechnology·Yanhong Li, Xi Chen
Jun 19, 2010·Journal of the American Chemical Society·Thomas J Morley, Stephen G Withers
Dec 7, 2011·Infection and Immunity·Stanley M SpinolaRobert S Munson
Feb 7, 2014·Standards in Genomic Sciences·Shun FujinamiNobuyuki Fujita
Jan 27, 2015·Applied Microbiology and Biotechnology·Fang ChenBai-Xue Lin
Nov 29, 2011·Biotechnology Advances·Nam Soo HanJin-Ho Seo
Aug 21, 2009·Natural Product Reports·Gerd K WagnerRobert A Field
Dec 10, 2009·Chembiochem : a European Journal of Chemical Biology·Raphael BöhmThomas Haselhorst
Jan 14, 2011·Bioscience, Biotechnology, and Biochemistry·Hitomi KajiwaraTakeshi Yamamoto
Jul 6, 2019·Frontiers in Microbiology·Elisabeth LavilleGabrielle Potocki-Veronese
Jul 18, 2020·Viruses·Jasmine L MadrigalMelissa K Jones
Apr 27, 2016·The Biochemical Journal·Ilya B MertsalovVladislav M Panin
Jun 18, 2019·Acta Crystallographica. Section D, Structural Biology·Sucharita BoseRamaswamy Subramanian
Oct 26, 2018·Emerging Topics in Life Sciences·Asher WilliamsMattheos A G Koffas
Jul 22, 2021·Biotechnology and Bioengineering·Sabine SchelchBernd Nidetzky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

© 2022 Meta ULC. All rights reserved