PMID: 15372112Sep 17, 2004Paper

Bacterial colonization and the development of intestinal defences

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
Hai Ning Shi, Allan Walker

Abstract

In humans, intestinal defences develop during gestation and, at full term, have the capacity to respond in an appropriate manner to infectious agents and foreign antigens. Before an active protective response can occur, however, the gut must first be exposed to colonizing bacteria. Colonization with diverse intestinal microbes is necessary for the development of important gut defenses such as the synthesis and secretion of polymeric immunoglobulin A and the generation of a balanced T helper (Th) cell response. Insights into normal immune physiological development of the gut have been made by studying the germ-free animal and intestinal defenses. These studies have provided insights into the physiology of immune responses. Two important immunological functions are the secretion of polymeric immunoglobulin A to protect the intestinal surface against harmful stimuli and inhibition of the systemic response to commensal bacteria and food proteins (eg, oral tolerance) to prevent chronic inflammation. Neither function exists in the germ-free state, but rapidly develops after conventionalization (colonization) of the germ-free animal. In the present review, the importance of bacterial colonization on the appearance of normal mucosal im...Continue Reading

Citations

Jan 11, 2007·Pediatric Research·David S Newburg, W Allan Walker
Aug 8, 2008·Journal of Clinical Gastroenterology·Roberto Berni CananiAlfredo Guarino
Jan 8, 2010·Journal of Clinical Gastroenterology·Natasha Walzer, Alan L Buchman
Jun 15, 2011·Leukemia & Lymphoma·Stephen Murphy, Vu H Nguyen
Jan 16, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·S DangN Desai
Jan 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W Allan Walker
Jul 11, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·A R Bedford Russell, S H Murch
Feb 7, 2009·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Deborah A Lindberg
Feb 23, 2013·Neonatology·Andrea S WeintraubAnnemarie Stroustrup
Apr 25, 2006·Journal of Dental Research·J SodekR Zohar
Mar 11, 2009·Diseases of the Colon and Rectum·John Calvin CoffeyWilliam Oliver Kirwan
Apr 29, 2015·Gut and Liver·Sean M P BennetMagnus Simren
May 14, 2016·Nature Communications·Mi Young YoonSang Sun Yoon
Jan 27, 2010·The British Journal of Nutrition·Haleh Sadrzadeh-YeganehMaryam Chamary
Nov 26, 2015·International Reviews of Immunology·Fiona Long Yan FongHani El-Nezami
Jan 8, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Beth Taylor, Joe Krenitsky
Oct 7, 2006·Nature Reviews. Immunology·Sarkis K Mazmanian, Dennis L Kasper
Jan 23, 2009·Digestive Diseases and Sciences·Marleen T J van AmptingIngeborg M J Bovee-Oudenhoven
Oct 21, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ashok BuchiboyinaSanjay Patole
Aug 30, 2005·Advances in Pediatrics·Chien-Chang Chen, W Allan Walker

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