Bacterial colonization of the stomach and duodenum in a Swedish population with and without proton pump inhibitor treatment

JGH Open : an Open Access Journal of Gastroenterology and Hepatology
Jorge Alberto Arroyo VázquezMaria Bergström

Abstract

Microbial contamination of the abdominal cavity is a serious concern during transgastric endoscopic interventions and perforations, particularly in patients who have inhibited gastric acid secretion due to treatment with proton pump inhibitors (PPIs).The aim of this study was to investigate the gastric and duodenal bacterial flora in patients with and without PPI treatment. Patients referred for gastroscopy, without recent antibiotic treatment, were eligible for inclusion. Use of PPIs was recorded. Samples for bacterial culturing were obtained from the antrum of the stomach and from the duodenal bulb through a gastroscope. Positive cultures were examined for bacterial types and subtypes. Biopsies were taken in the antrum for urease test to detect Helicobacter pylori. Bacterial cultures from the stomach were obtained from 103 patients, and duodenal samples were also cultured from 49 of them, for a total of 53 patients with PPI use and 50 patients without. Positive gastric cultures were found in 42 of 53 patients with PPI use and in 13 of 50 without (P < 0.0001). Duodenal cultures were positive in 20 of 24 with PPI and 8 of 25 without (P < 0.0001). The most commonly identified bacterial species were oral strains of Streptococcus,...Continue Reading

References

Sep 1, 1992·Journal of Gastroenterology and Hepatology·S NaliniK A Balasubramanian
May 1, 1982·American Journal of Surgery·J BoeyG B Ong
Aug 27, 1997·JAMA : the Journal of the American Medical Association·A HurwitzC E Ruhl
Apr 14, 2000·Journal of Gastroenterology and Hepatology·K HarumaA Miyoshi
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinUNKNOWN Infectious Diseases Society of America
Aug 24, 2004·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K KrobotW Sendt
Jan 12, 2005·World Journal of Gastroenterology : WJG·Ari Fahrial SyamTadashi Sato
Feb 1, 2005·Basic & Clinical Pharmacology & Toxicology·Tom C MartinsenHelge L Waldum
Jan 6, 2006·Alimentary Pharmacology & Therapeutics·C Williams, K E L McColl
Mar 11, 2009·Journal of Medical Microbiology·Johan DicksvedLars Engstrand
Apr 11, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Huan SongWeimin Ye

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Citations

Jun 12, 2021·Current Opinion in Physiology·Carolina SerranoDiane Bimczok

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Methods Mentioned

BETA
biopsy

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Researchweb
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