Bacterial contamination rates following processing of bone marrow and peripheral blood progenitor cell preparations

Transfusion
D PadleyR G Strauss

Abstract

The performance of cultures to assess possible bacterial contamination of bone marrow and peripheral blood progenitor cell preparations is required by the standards of the American Association of Blood Banks. Consecutive (n = 893) bone marrow and peripheral blood progenitor cell preparations were cultured for assessment of possible contamination by microorganisms. Consecutive bone marrow and peripheral blood progenitor cell preparations (n = 893) were cultured; the overall positive rate detected was 2.5 percent (22/893). The isolates predominantly were skin contaminants (gram-positive cocci) and so-called water-borne organisms (gram-negative rods). The 6.0-percent rate of positivity in 317 bone marrow preparations was higher than the 0.5-percent rate in 576 peripheral blood progenitor cell preparations (p < 10(-6)). Culture-positive preparations were transfused to 16 patients at this institution; however, none of these transfusions led to documented sepsis with the contaminating organism. The culture method described here complies with the standards of the American Association of Blood Banks. Contamination can be detected in both bone marrow and peripheral blood progenitor cell preparations. When contaminated preparations are t...Continue Reading

Citations

Mar 10, 2000·Computer Methods and Programs in Biomedicine·P L Perrotta, P M Nadkarni
Feb 3, 2007·American Journal of Hematology·David BerzPeter J Quesenberry
Oct 22, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Lia MelePiero Borzini
Jan 1, 1999·Cytotherapy·A P Gee
Nov 7, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mark A KleinLinda J Burns
Aug 1, 2012·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Igor Dullius AlmeidaLuciano Zubaran Goldani
May 24, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Imad KassisHannah Sprecher
Jan 10, 2001·Bone Marrow Transplantation·C R de MedeirosR Pasquini

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