PMID: 9548974Jun 13, 1998Paper

Bacterial contig map of the 21q11 region associated with Alzheimer's disease and abnormal myelopoiesis in Down syndrome

Genome Research
J GroetD Nizetic

Abstract

We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11-q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheimer's Disease that has never been explained. The map contains 89 overlapping PACs, BACs, or cosmids in three contigs (850, 850, and 1500 kb) with two gaps (one of 140-210 kb and the second <5 kb). To date, eight transcribed sequences derived by cDNA selection, exon trapping, and/or global EST sequencing have been positioned onto the map, and the only two genes so far mapped to this cytogenetic region, STCH and RIP140 have been precisely localized. This work converts a further 10% of chromosome 21q into a high-resolution bacterial contig map, which will be the physical basis for the long-range sequencing of this region. The map will also enable positional derivation of new transcribed sequences, as well as new polymorphic probes, that will help in elucidation of the role the genes in this region may play in abnormal myelopoiesis and leukemia associated with trisomy 21 and Alzheimer's Disease.

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Citations

Apr 23, 2008·Current Protocols in Human Genetics·Robert M GemmillRod A Wing
Jan 11, 2013·The Journal of Biological Chemistry·Jun-Seok BaeKyungpyo Park
Jun 10, 2003·American Journal of Medical Genetics. Part a·Hilary Tinkel-VernonLeonard Sciorra
Mar 7, 2021·International Journal of Molecular Sciences·Dalal Bakhos-DouaihyKamel Laghmani
Nov 30, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T A JonesD Sheer

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