Bacterial contribution to genesis of the novel germ line determinant oskar

BioRxiv : the Preprint Server for Biology
Leo BlondelCassandra G Extavour

Abstract

New cellular functions and developmental processes can evolve by modifying existing genes or creating novel genes. Novel genes can arise not only via duplication or mutation but also by acquiring foreign DNA, also called horizontal gene transfer (HGT). Here we show that HGT likely contributed to the creation of a novel gene indispensable for reproduction in some insects. Long considered a novel gene with unknown origin, oskar has evolved to fulfil a crucial role in insect germ cell formation. Our analysis of over 100 insect Oskar sequences suggests that Oskar arose de novo via fusion of eukaryotic and prokaryotic sequences. This work shows that highly unusual gene origin processes can give rise to novel genes that can facilitate evolution of novel developmental mechanisms.

Related Concepts

Conserved Sequence
DNA
Biological Evolution
Gene Rearrangement
Genes
Genome
Germ Cells
Insecta
Lipase
Membrane Fusion

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