Bacterial CRISPR Regions: General Features and their Potential for Epidemiological Molecular Typing Studies

The Open Microbiology Journal
Zahra KarimiReza Ranjbar

Abstract

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) loci as novel and applicable regions in prokaryotic genomes have gained great attraction in the post genomics era. These unique regions are diverse in number and sequence composition in different pathogenic bacteria and thereby can be a suitable candidate for molecular epidemiology and genotyping studies. Results:Furthermore, the arrayed structure of CRISPR loci (several unique repeats spaced with the variable sequence) and associated cas genes act as an active prokaryotic immune system against viral replication and conjugative elements. This property can be used as a tool for RNA editing in bioengineering studies. The aim of this review was to survey some details about the history, nature, and potential applications of CRISPR arrays in both genetic engineering and bacterial genotyping studies.

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Citations

May 18, 2019·Molecular Genetics and Genomics : MGG·Ana Carolina de Oliveira LuzTereza Cristina Leal-Balbino
Jan 22, 2021·Journal of Medical Microbiology·Luís Guilherme de Araújo LongoBeatriz Meurer Moreira
Dec 5, 2020·Scientific Reports·Simran Krishnakant KushwahaSandhya Amol Marathe
Dec 16, 2020·Animals : an Open Access Journal From MDPI·Koeun KimYoung Ju Lee
Apr 28, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mahnaz Shafaei FallahEzzat Allah Ghaemi
May 23, 2021·Molecular Biotechnology·Arpit ShuklaDhara Patel

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

CRISPR Recognition tool ( CRT )
CR
CRISPI
PILER
CRISPR Finder

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