PMID: 9423877Jan 10, 1998Paper

Bacterial cytolysin perturbs round window membrane permeability barrier in vivo: possible cause of sensorineural hearing loss in acute otitis media

Infection and Immunity
F EngelS Bhakdi

Abstract

The passage of radioiodinated streptolysin-O (SLO) and albumin through the round window membrane (RWM) was studied in vivo. When applied to the middle ear, SLO became quantitatively entrapped in this compartment and no passage to the cochlea occurred. However, flux of radioiodinated albumin through the toxin-damaged RWM was observed. We propose that the passage of noxious macromolecules, such as proteases, from a purulent middle-ear effusion may be facilitated by pore-forming toxins, resulting in cochlear damage and sensorineural hearing loss.

References

Jan 1, 1990·Archives of Otolaryngology--head & Neck Surgery·K IkedaS K Juhn
Jan 1, 1989·Acta Oto-laryngologica. Supplementum·H KawauchiD J Lim
Jan 1, 1987·Reviews of Physiology, Biochemistry and Pharmacology·S Bhakdi, J Tranum-Jensen
Oct 1, 1987·The Laryngoscope·M M PaparellaH Sajjadi
Aug 1, 1988·Archives of Otolaryngology--head & Neck Surgery·K Ikeda, T Morizono
Jun 1, 1987·Archives of Otolaryngology--head & Neck Surgery·P A SchachernY B Choo
Jan 1, 1985·Infection and Immunity·S BhakdiA Sziegoleit
Nov 1, 1984·Infection and Immunity·S BhakdiJ Tranum-Jensen
Nov 1, 1984·The Annals of Otology, Rhinology, and Laryngology·M M PaparellaC S Kim
Feb 1, 1980·International Journal of Pediatric Otorhinolaryngology·M V GoycooleaA M Carpenter
Jul 15, 1995·European Journal of Biochemistry·M PalmerS Bhakdi
Sep 1, 1993·Medical Microbiology and Immunology·S BhakdiM Palmer

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Citations

Jul 23, 2008·Experimental Dermatology·Martin MetzMarcus Maurer
Jun 18, 2010·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hongjun XiaoNa Zheng
Nov 22, 2019·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Amit Kumar RanaSurendra Prasad
May 12, 2000·The Laryngoscope·P J AntonelliK J Gerhardt
Feb 7, 2004·The Annals of Otology, Rhinology, and Laryngology·Andreas NeherJosef M Miller
Jul 1, 2004·The Annals of Otology, Rhinology, and Laryngology·Michihiko SoneTsutomu Nakashima
Oct 17, 2003·Neuroreport·Mitsuya SuzukiKimitaka Kaga
Dec 1, 2005·International Journal of Audiology·Luca Oscar Redaelli de ZinisAntonino Roberto Antonelli
Sep 21, 2012·Acta Oto-laryngologica·Adnan LidianLeif Nordang
Apr 19, 2016·The Journal of Laryngology and Otology·R L HeywoodA A Narula
Apr 24, 2002·The Annals of Otology, Rhinology & Laryngology. Supplement·Cuneyt M AlperTomonori Takasaka
Mar 1, 2003·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Kamaljit KaurA S Bapna
Mar 1, 2020·Hearing Research·Lisa L HunterJonathan H Siegel

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