PMID: 7336755Nov 1, 1981Paper

Bacterial degradation of aminopyrine

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
H BlecherF Lingens

Abstract

1. Four strains of bacteria growing with aminopyrine as sole source of carbon were isolated from soil and were identified as strains of Phenylobacterium immobilis. 2. Strain M13 and strain E, the type species of Phenylobacterium immobilis (DSM 1986), which had been isolated by enrichment with chloridazon (5-amino-4-chloro-2-phenyl-2H-pyridazin-3-one) were used to investigate the bacterial degradation of aminopyrine. 3. Three metabolites were isolated and identified as: 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-(2,3-dihydro-2,3-dihydroxy-4,6-cyc lohexadien-1-yl)-3H-pyrazol-3-one, 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-(2,3-dihydroxyphenyl)-3H-pyrazol-3 -one and 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-3H-pyrazol-3-one. 4. An enzyme extract from cells of strain m13 was shown to further metabolize the catechol derivative of aminopyrine, with the formation of 2-pyrone-6-carboxylic acid. 5. Results indicate that the benzene ring of aminopyrine is the principal site of microbial metabolism.

References

Mar 15, 1977·European Journal of Biochemistry·K SauberF Lingens
Mar 1, 1973·European Journal of Biochemistry·E De FrenneF Lingens
Sep 18, 1973·Biochemical and Biophysical Research Communications·S HaugF Lingens

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Citations

Jun 1, 1994·Journal of Pharmaceutical and Biomedical Analysis·J SmisterováR A De Zeeuw
Jan 1, 1988·General Pharmacology·F Y MalikS J Jabbur
Jan 1, 1983·Systematic and Applied Microbiology·G LayhF Lingens
Jun 4, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Björn HeismannDavid Grodzki

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